Evidence map›Paper›PMID 38295876›Full record

ReviewJournal of advanced research2025

Mechanisms and therapeutic implications of selective autophagy in nonalcoholic fatty liver disease.

Suwei Jin, Yujia Li, Tianji Xia, Yongguang Liu, Shanshan Zhang, Hongbo Hu, Qi Chang, Mingzhu Yan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Role of autophagy in antiviral innate immunity.Cellular & molecular biology letters · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suwei JinInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
Yujia LiDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Tianji XiaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
Yongguang LiuInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
Shanshan ZhangInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
Hongbo HuCollege of Food Science and Nutritional Engineering, China Agricultural University, China. Electronic address: hongbo@cau.edu.cn.
Qi ChangInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address: qchang@implad.ac.cn.
Mingzhu YanInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, China. Electronic address: mzyan@implad.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide, whereas there is no approved drug therapy due to its complexity. Studies are emerging to discuss the role of selective autophagy in the pathogenesis of NAFLD, because the specificity among the features of selective autophagy makes it a crucial process in mitigating hepatocyte damage caused by aberrant accumulation of dysfunctional organelles, for which no other pathway can compensate. AIM OF REVIEW: This review aims to summarize the types, functions, and dynamics of selective autophagy that are of particular importance in the initiation and progression of NAFLD. And on this basis, the review outlines the therapeutic strategies against NAFLD, in particular the medications and potential natural products that can modulate selective autophagy in the pathogenesis of this disease. KEY SCIENTIFIC CONCEPTS OF REVIEW: The critical roles of lipophagy and mitophagy in the pathogenesis of NAFLD are well established, while reticulophagy and pexophagy are still being identified in this disease due to the insufficient understanding of their molecular details. As gradual blockage of autophagic flux reveals the complexity of NAFLD, studies unraveling the underlying mechanisms have made it possible to successfully treat NAFLD with multiple pharmacological compounds that target associated pathways. Overall, it is convinced that the continued research into selective autophagy occurring in NAFLD will further enhance the understanding of the pathogenesis and uncover novel therapeutic targets.

Indexed as

AutophagyMitophagyNon-alcoholic Fatty Liver DiseaseAnimalsHepatocytesHumansLiverAutophagic fluxNonalcoholic fatty liver diseaseSelective autophagyTherapeutic targets

Identifiers

PMID38295876
PMCPMC11725165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.