ArticleScience translational medicine2024
Myeloid and lymphoid expression of
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Gut microbiota and ALS: cause, consequence or correlation? - a systematic review.Frontiers in neuroscience · 2026Pooled it
- Clonal CD8 T cells link peripheral and intrathecal immunity in ALS4 progression: a multiomics reference for ALS.Research square · 2026Article
- The C9orf72/SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair.The EMBO journal · 2026Article
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Immune imbalance between T helper 1, T helper 17 and regulatory T cells fuels amyotrophic lateral sclerosis pathogenesis: disease trajectory, diagnosis and therapeutic implications.Journal of neuroinflammation · 2026Review
- PU.1 restores microglial dysfunction caused by C9ORF72 repeat expansions in neural organoids.Brain : a journal of neurology · 2026Article
- C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen.Cell reports · 2026Article
- Article
- A Multi-Omics Integration Framework with Automated Machine Learning Identifies Peripheral Immune-Coagulation Biomarkers for Schizophrenia Risk Stratification.International journal of molecular sciences · 2025Article
- Review
- Review
- Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics.The Lancet. Neurology · 2025Review
- C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS-STING Pathway.Immunity, inflammation and disease · 2025Article
- C9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia.Annals of translational medicine · 2024Article
- The Current Landscape of Hypotheses Describing the Contribution of CD4+ Heterogeneous Populations to ALS.Current issues in molecular biology · 2024Article
- Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS.Nature aging · 2024Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 4 institutions in 3 countries.
Francesco LimoneDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-2482-8801
Alexander CoutoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Jin-Yuan WangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Yingying ZhangDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-3435-1330
Blake McCourtDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-1488-2572
Cerianne HuangDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Adina MinkinDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0009-0002-3442-7216
Marghi JaniDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Sarah McNeerDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0003-3469-3231
James KeaneyNeuroinflammation Focus Area, UCB Biopharma SRL, Braine-l'Alleud 1420, Belgium.
Gaëlle GilletNeuroinflammation Focus Area, UCB Biopharma SRL, Braine-l'Alleud 1420, Belgium.ORCID 0009-0002-7477-3279
Rodrigo Lopez GonzalezDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44196, USA.ORCID 0000-0002-5480-6312
Wendy A GoodmanDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-6864-0384
Irena KadiuNeuroinflammation Focus Area, UCB Biopharma SRL, Braine-l'Alleud 1420, Belgium.
Kevin EgganDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-4436-8467
Aaron BurberryDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-1552-8695
Broad Institute · USCase Western Reserve University · USUCB Pharma (Belgium) · BECleveland Clinic Lerner College of Medicine · US
Funding
Pathogenesis of Neurological Disability in Primary Diseases of MyelinR35NS097303 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI TRAPP, BRUCE D · 2017 to 2024
$6.9MImmunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4MC9ORF72 in Motor System Biology and ALSR01NS089742 · NINDS · HARVARD UNIVERSITY · PI EGGAN, KEVIN C · 2014 to 2018
$2.3MEstrogen-mediated immune regulation in human and experimental inflammatory bowel diseaseR01DK128143 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI GOODMAN, WENDY ANN · 2021 to 2025
$2.2MIdentifying T cell determinants of heritable Frontotemporal dementiaR01AG085316 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI Aaron Burberry · 2024 to 2026
$1.8MThe Alzheimer's Disease Translational Data Science Training ProgramT32AG071474 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BUSH, WILLIAM S · 2021 to 2025
$1.1MExploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral SclerosisR00AG057808 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BURBERRY, AARON · 2021 to 2023
$747kBacterial triggers of neural inflammation.R03AG080175 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BURBERRY, AARON · 2023 to 2024
$322kIntermediate-Featured Flow CytometerS10OD021559 · OD · CASE WESTERN RESERVE UNIVERSITY · PI JACOBBERGER, JAMES W · 2016 to 2016
$230kExploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral SclerosisK99AG057808 · NIA · HARVARD UNIVERSITY · PI BURBERRY, AARON · 2018 to 2019
$217kNIAID NIH HHS T32 AI089474NIA NIH HHS K99 AG057808NIA NIH HHS R00 AG057808NIA NIH HHS R01 AG085316NIA NIH HHS R03 AG080175NIA NIH HHS T32 AG071474NIDDK NIH HHS R01 DK128143NIH HHS S10 OD021559NINDS NIH HHS R01 NS089742NINDS NIH HHS R35 NS097303
Abstract
A mutation in
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaAnimalsEndothelial CellsHumansInterleukin-17MiceNeuroinflammatory DiseasesC9orf72 ProteinC9orf72 protein, humanC9orf72 protein, mouseInterleukin-17
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.