Evidence map›Paper›PMID 38295154›Full record

ArticleOrganic letters2024

Accessing Medium-Sized Rings via Vinyl Carbocation Intermediates.

Zhenqi Zhao, Stasik Popov, Woojin Lee, Jessica E Burch, David A Delgadillo, Lee Joon Kim, Mona Shahgholi, Naiara Lebrón-Acosta, K N Houk, Hosea M Nelson

Abstract read
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In one paragraph

Article in Organic letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenqi ZhaoDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Stasik PopovDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Woojin LeeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-8531-0301
Jessica E BurchDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
David A DelgadilloDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-0897-4470
Lee Joon KimDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.
Mona ShahgholiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Naiara Lebrón-AcostaDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-8387-5261
Hosea M NelsonDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4666-2793

Funding

Kinetically-Persistent Carbocationsin C-H Insertion Reactions and Biomimetic Cyclization CascadesR35GM128936 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NELSON, HOSEA MARTIN · 2018 to 2022
$1.9M
NIGMS NIH HHS R35 GM128936
6 · The paper itself

Abstract

Medium-sized rings (8-11-membered cycles) are often more challenging to synthesize than smaller rings (5-7-membered cycles) due to ring strain. Herein, we report a catalytic method for forming 8- and 9-membered rings that proceeds via the intramolecular Friedel-Crafts reactions of vinyl carbocation intermediates. These reactive species are generated catalytically through the ionization of vinyl toluenesulfonates by a Lewis acidic lithium cation-weakly coordinating anion salt.

Identifiers

PMID38295154
PMCPMC10863392

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.