Evidence map›Paper›PMID 38294982›Full record

ArticleThe New England journal of medicine2024

Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia.

Veronica J Alexander, Ewa Karwatowska-Prokopczuk, Thomas A Prohaska, Lu Li, Richard S Geary, Ioanna Gouni-Berthold, Elif A Oral, Robert A Hegele, Erik S G Stroes, Joseph L Witztum and 1 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
42.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Advances in Non-statin Lipid Therapies: A Narrative Review of Evolving Strategies for Cardiovascular Risk Reduction.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
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  12. Article
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  15. Article
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  17. Article
  18. Article
  19. MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis.Apoptosis : an international journal on programmed cell death · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Veronica J AlexanderIonis Pharmaceuticals, Carlsbad, CA.
Ewa Karwatowska-ProkopczukIonis Pharmaceuticals, Carlsbad, CA.
Thomas A ProhaskaIonis Pharmaceuticals, Carlsbad, CA.
Lu LiIonis Pharmaceuticals, Carlsbad, CA.
Richard S GearyIonis Pharmaceuticals, Carlsbad, CA.
Ioanna Gouni-BertholdUniversity of Cologne, Cologne, Germany.
Elif A OralUniversity of Michigan, Ann Arbor, MI.
Robert A HegeleWestern University, London, ON, Canada.ORCID 0000-0003-2861-5325
Erik S G StroesAcademic Medical Center, Amsterdam, the Netherlands.
Joseph L WitztumUniversity of California, San Diego, La Jolla, CA stsimikas@health.ucsd.edu.
Sotirios TsimikasUniversity of California, San Diego, La Jolla, CA stsimikas@health.ucsd.edu.ORCID 0000-0001-9834-9494
Ionis Pharmaceuticals (United States) · USUC San Diego Health System · USAmsterdam UMC Location University of Amsterdam · NLUniversity of Cologne · DEUniversity of Michigan · USWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HypertriglyceridemiaOligonucleotidesPancreatitisAcute DiseaseHumansHyperlipidemiasTriglyceridesISIS 304801OligonucleotidesTriglycerides

Identifiers

PMID38294982
OpenAlexW4391378948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.