Evidence map›Paper›PMID 38294715›Full record

ReviewCurrent osteoporosis reports2024

Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing.

Murad K Nazzal, Ashlyn J Morris, Reginald S Parker, Fletcher A White, Roman M Natoli, Melissa A Kacena, Jill C Fehrenbacher

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Murad K Nazzal *Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Ashlyn J Morris *Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Reginald S Parker *Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Fletcher A WhiteIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Roman M NatoliDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Melissa A KacenaDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. mkacena@iupui.edu.
Jill C FehrenbacherIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA. jfehrenb@iu.edu.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Comprehensive Training Program in Musculoskeletal ResearchT32AR065971 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ALEXANDER G ROBLING · 2015 to 2026
$4.4M
Angiogenic Therapy: Novel Approaches to Enhance Bone Regeneration in Aging - LOADR01AG060621 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KACENA, MELISSA A, LI, JILIANG · 2019 to 2023
$3.7M
Short-Term Training Program In Biomedical SciencesT35HL110854 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Brittney-Shea Herbert, Catherine Rufatto Sears · 2012 to 2026
$3.4M
Impact of TPO Treatment on Bone Healing and Angiogenesis in Type 2 DiabetesI01BX003751 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2017 to 2021
–
RR&D Research Career Scientist Award ApplicationIK6RX004809 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2023 to 2025
–
"Novel therapeutic approaches to improve fracture healing while reducing pain behavior"I01RX003552 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2022 to 2025
–
BLRD VA I01 BX003751BLRD VA I01 BX006399NCATS NIH HHS UL1 TR002529NHLBI NIH HHS T35 HL110854NIAMS NIH HHS T32 AR065971NIA NIH HHS R01 AG060621NIH HHS AG060621NIH HHS AR065971NIH HHS HL110854RRD VA I01 RX003552RRD VA IK6 RX004809
6 · The paper itself

Abstract

purpose of reviewFractures are a prominent form of traumatic injury and shall continue to be for the foreseeable future. While the inflammatory response and the cells of the bone marrow microenvironment play significant roles in fracture healing, the nervous system is also an important player in regulating bone healing. RECENT

findingsConsiderable evidence demonstrates a role for nervous system regulation of fracture healing in a setting of traumatic injury to the brain. Although many of the impacts of the nervous system on fracture healing are positive, pain mediated by the nervous system can have detrimental effects on mobilization and quality of life. Understanding the role the nervous system plays in fracture healing is vital to understanding fracture healing as a whole and improving quality of life post-injury. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.

Indexed as

Fracture HealingFractures, BoneArtificial IntelligenceBony CallusHumansQuality of LifeAIArtificial intelligenceCentral nervous systemChatGPTFracturePainPeripheral nervous system

Identifiers

PMID38294715
PMCPMC10912323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.