Evidence map›Paper›PMID 38294627›Full record

ArticleJournal of cardiovascular translational research2024

Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.

Guanglang Zhu, Yang Li, Hongxia Gao, Xu Li, Heyu Fan, Longhua Fan

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guanglang ZhuDepartment of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, 1158 Park Road, Qingpu, Shanghai, 201700, People's Republic of China.
Yang LiDepartment of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Hongxia GaoDepartment of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, 1158 Park Road, Qingpu, Shanghai, 201700, People's Republic of China.
Xu LiDepartment of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, 1158 Park Road, Qingpu, Shanghai, 201700, People's Republic of China.
Heyu FanSchool of Arts and Sciences, Rutgers University, New Brunswick, NJ, USA.
Longhua FanDepartment of Vascular Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, 1158 Park Road, Qingpu, Shanghai, 201700, People's Republic of China. longhuafanzsh@163.com.ORCID 0009-0001-6247-8566

Funding

Natural Science Foundation of Shanghai Municipality 20ZR1411800Natural Science Foundation of Shanghai Municipality 22ZR1412100
6 · The paper itself

Abstract

In this study, we investigated the protective role of Mzb1 in atherosclerotic plaque vulnerability. To explore the impact of Mzb1, we analyzed Mzb1 expression, assessed apoptosis, and evaluated mitochondrial function in atherosclerosis (AS) mouse models and human vascular smooth muscle cells (HVSMCs). We observed a significant decrease in Mzb1 expression in AS mouse models and ox-LDL-treated HVSMCs. Downregulation of Mzb1 increased ox-LDL-induced apoptosis and cholesterol levels of HVSMCs, while Mzb1 overexpression alleviated these effect. Mzb1 was found to enhance mitochondrial function, as evidenced by restored ATP synthesis, mitochondrial membrane potential, and reduced mtROS production. Moreover, Mzb1 overexpression attenuated atherosclerotic plaque vulnerability in ApoE

Indexed as

AMP-Activated Protein KinasesApoptosisAtherosclerosisDisease Models, AnimalMice, Inbred C57BLMice, Knockout, ApoEMuscle, Smooth, VascularMyocytes, Smooth MusclePlaque, AtheroscleroticSignal TransductionSirtuin 1Adenosine TriphosphateAnimalsAortaAortic DiseasesApolipoproteins EAdenosine TriphosphateAMP-Activated Protein KinasesApoe protein, mouseApolipoproteins ELipoproteins, LDLoxidized low density lipoproteinSirt1 protein, mouseSirtuin 1ApoptosisHuman vascular smooth muscle cellsMitochondriaMzb1Plaque vulnerability

Identifiers

PMID38294627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.