Evidence map›Paper›PMID 38294625›Full record

ArticleSleep & breathing = Schlaf & Atmung2024

Validation of the Apnealink Air for diagnosis of obstructive sleep apnoea (OSA) in pregnant women in early-mid gestation.

Frances Clements, Angela Makris, Yewon Chung, Nathaniel S Marshall, Kerri Melehan, Renuka Shanmugalingam, Annemarie Hennessy, Hima Vedam

Abstract readValidation StudyComparative Study
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Frances ClementsDepartment of Respiratory and Sleep Medicine, Liverpool Hospital, South Western Sydney Local Health District, Liverpool, New South Wales, Australia. Frances.clements@health.nsw.gov.au.ORCID 0000-0002-3146-6028
Angela MakrisSchool of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia.ORCID 0000-0002-1636-3493
Yewon ChungDepartment of Respiratory and Sleep Medicine, Liverpool Hospital, South Western Sydney Local Health District, Liverpool, New South Wales, Australia.ORCID 0000-0003-0692-6608
Nathaniel S MarshallWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0002-9014-1397
Kerri MelehanFaculty of Medicine and Health, University of Sydney, Sydney, Australia.ORCID 0000-0002-2022-5739
Renuka ShanmugalingamSchool of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia.ORCID 0000-0002-2255-8369
Annemarie HennessySchool of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia.ORCID 0000-0002-5975-2843
Hima VedamDepartment of Respiratory and Sleep Medicine, Liverpool Hospital, South Western Sydney Local Health District, Liverpool, New South Wales, Australia.ORCID 0000-0002-0515-8670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe detection of obstructive sleep apnoea (OSA) in pregnant women in early-mid gestation is logistically difficult. Accurate alternates to polysomnography (PSG) in early pregnancy are not well identified. We compared the agreement between Apnealink Air (AL) and existing screening questionnaires to PSG in pregnant women ≤ 24-week gestation.

methodsPregnant women (≤ 24-week gestation) underwent AL at home plus attended PSG in any order, completed within 7 days where practicable. AL was manually scored (AL(M)) and automatically scored (AL(A)). An apnoea-hypopnea index (AHI) ≥ 5 was considered diagnostic of OSA and an AHI ≥ 15 considered at least moderate OSA. Diagnostic analysis was undertaken (sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV)) by generating receiver operating characteristic (ROC) curves and an area under the curve (AUC) (95% CI). Bland-Altman plots were used to plot agreement. Screening questionnaires (Epworth sleepiness score (ESS), STOP-BANG, calculated pregnancy-specific screening tool) were compared to PSG.

resultsA total of 49 participants successfully completed both tests at around 14-weeks gestation (IQR 12.9, 17.1). The time interval between AL and PSG was a median of 2 days (IQR 1, 5 (range 1-11)). A total of 14 (29%) participants had OSA. The median AHI of AL(A) (3.1(IQR 0.85,4.6)) and AL(M) (IQR2.4(0.65,4.8)) did not differ from PSG (1.7(IQR1.0,6.1)). AL(A) and AL(M) compared to PSG demonstrated diagnostic test accuracy (area under curve (ROC)) of 0.94(95% CI 0.87-1.0) and 0.92(95% CI 0.85-1.0) respectively. Apnealink Air outperformed screening questionnaires tested.

conclusionThe findings suggest that Apnealink may provide a substitute to attended PSG identification of OSA in pregnant women in early-mid gestation using both manual and auto-scoring methods.

Indexed as

PolysomnographyPregnancy ComplicationsSleep Apnea, ObstructiveAdultFemaleHumansPregnancyPregnancy Trimester, SecondSurveys and QuestionnairesObstetric medicineObstructive sleep apnoeaPolysomnographyPregnancySleep diagnosticsSleep disordered breathingValidation

Identifiers

PMID38294625

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.