Evidence map›Paper›PMID 38294608›Full record

ArticleNeuromolecular medicine2024

Amelioration of Astrocyte-Mediated Neuroinflammation by EI-16004 Confers Neuroprotection in an MPTP-induced Parkinson's Disease Model.

Jaehoon Kim, Seulah Lee, Dong Geun Hong, Seonguk Yang, Cong So Tran, Jinsook Kwak, Min-Ju Kim, Thenmozhi Rajarathinam, Ki Wung Chung, Young-Suk Jung and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Jaehoon KimCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Seulah LeeCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Dong Geun HongCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Seonguk YangCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Cong So TranCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jinsook KwakCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Min-Ju KimCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Thenmozhi RajarathinamDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241, Republic of Korea.
Ki Wung ChungCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Young-Suk JungCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Akihito IshigamiMolecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173-0015, Japan.
Seung-Cheol ChangDepartment of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241, Republic of Korea.
Haeseung LeeCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Hwayoung YunCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Jaewon LeeCollege of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea. neuron@pusan.ac.kr.
Pusan National University · KRTokyo Metropolitan Institute of Gerontology · JP

Funding

National Research Foundation of Korea NRF-2021R1A2C1010091
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that results in motor impairment due to dopaminergic neuronal loss. The pathology of PD is closely associated with neuroinflammation, which can be characterized by astrocyte activation. Thus, targeting the inflammatory response in astrocytes might provide a novel therapeutic approach. We conducted a luciferase assay on an in-house chemical library to identify compounds with anti-inflammatory effects capable of reducing MPP

Indexed as

NeuroprotectionParkinson DiseaseAnimalsAnti-Inflammatory AgentsAstrocytesDopamineMaleMiceMice, Inbred C57BLNeuroinflammatory DiseasesAnti-Inflammatory AgentsDopamine1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineAstrocyteEI-16004NeuroinflammationNeuroprotectionParkinson’s Disease

Identifiers

PMID38294608
OpenAlexW4391401318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.