Observational studyIntensive care medicine2024
Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study.
Observational study in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07343232 (Safety and Efficacy of Normobaric Facemask Oxygen for Hypocapnia in Aneurysmal Subarachnoid Hemorrhage), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Normobaric Facemask Oxygen for Hypocapnia in Aneurysmal Subarachnoid Hemorrhage(FOCAL): A Prospective, Multicenter, Proof-of-concept Pilot Study
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of mortality and neurological outcomes with hypocapnia in adult patients with acute brain injury: an updated meta-analysis.Critical care (London, England) · 2026Pooled it
- Impact of oxygen and carbon dioxide levels on mortality in moderate to severe traumatic brain injury: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Effects of rapid chest compression technique on intracranial and cerebral perfusion pressures in acute neurocritical patients: a randomized controlled trial.Critical care (London, England) · 2025Trial
- Oxygen, carbon dioxide, and nitric oxide: role in the pathophysiology of obstructive sleep apnea.Medical gas research · 2027Review
- Mechanical ventilation in acute brain injury.Breathe (Sheffield, England) · 2026Review
- ARDS management in trauma patients.Intensive care medicine · 2026Review
- Utilization of Neuromuscular Blocking Agents in Acute Brain Injury and Associations with Outcomes: A Post Hoc Analysis of the ENIO Study.Neurocritical care · 2026Observational
- PaCOJournal of clinical medicine · 2026Review
- Spontaneous breathing trials as predictors of extubation outcomes in neurocritical care: insights from the ENIO study.Intensive care medicine · 2026Observational
- Extracorporeal Carbon Dioxide Removal in Acute Respiratory Distress Syndrome: Physiologic Rationale and Phenotype-Based Perspectives.Medicina (Kaunas, Lithuania) · 2026Review
- Survival outcomes, determinants, and hemodynamic trajectories with intravenous βFrontiers in pharmacology · 2026Article
- Effects of intraoperative hypercapnia on postoperative brain functional network connectivity and cognitive function in adult patients undergoing Clipping Intracranial Aneurysm.BMC neurology · 2025Article
- Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions.CNS neuroscience & therapeutics · 2025Review
- First Breath Matters: Out-of-Hospital Mechanical Ventilation in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Brain Protective Ventilation Strategies in Severe Acute Brain Injury.Current neurology and neuroscience reports · 2025Review
- Update on acute brain injury.Intensive care medicine · 2025Article
- Beyond the bleed: complications after aneurysmal subarachnoid hemorrhage. Pathophysiology, clinical implications, and management strategies: a review.Critical care (London, England) · 2025Review
- Expiratory Flow Bias and Physiological Effects of Rapid Chest Compression in Mechanically Ventilated Neurocritical Patients: A Secondary Analysis of a Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Capillary hemoglobin dynamics in COIntensive care medicine · 2025Article
- Capillary hemoglobin dynamics in CO₂ management after brain injury.Intensive care medicine · 2025Article
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of arterial partial pressure of carbon dioxide (PaCO
methodsWe carried out a secondary analysis of a multicenter prospective observational study involving adult invasively ventilated patients with traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), intracranial hemorrhage (ICH), or ischemic stroke (IS). PaCO
results1476 patients (65.9% male, mean age 52
conclusionsNormocapnia and mild hypocapnia are common in ABI patients and do not affect patients' outcome. Extreme derangements of PaCO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.