Evidence map›Paper›PMID 38294520›Full record

ArticleEuropean journal of nutrition2024

Serum zinc concentration and dietary zinc intake in relation to cognitive function: an analysis of the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.

Meghan Angley, Yijia Zhang, Liping Lu, Shai Bejerano, Frederick Unverzagt, John Brockman, Leslie A McClure, Suzanne Judd, Mary Cushman, Ka Kahe

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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meghan AngleyDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, 622 W 168th Street, Room 16-20, New York, NY, 10032, USA.
Yijia ZhangDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, 622 W 168th Street, Room 16-20, New York, NY, 10032, USA.
Liping LuDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, 622 W 168th Street, Room 16-20, New York, NY, 10032, USA.
Shai BejeranoDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, 622 W 168th Street, Room 16-20, New York, NY, 10032, USA.
Frederick UnverzagtDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
John BrockmanDepartment of Chemistry, University of Missouri Research Reactor, University of Missouri, Columbia, MI, USA.
Leslie A McClureDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Suzanne JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Ka KaheDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, 622 W 168th Street, Room 16-20, New York, NY, 10032, USA. kk3399@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-1451-3889

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
NIA NIH HHS RF1 AG056111NIH HHS RF1AG056111NIH HHS U01 NS041588NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

purposeThere are several pathways by which zinc may be a modifiable factor to slow age-related cognitive decline. We investigated the associations between serum and dietary zinc and cognitive impairment in a longitudinal cohort.

methodsWe used data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort (n = 30,239) and the REGARDS Trace Element Study (n = 2666). Baseline serum zinc concentrations (2003-2007) were measured using inductively coupled plasma mass spectrometry. Baseline dietary zinc intake was measured via the Block food frequency questionnaire. Serum zinc concentrations and dietary zinc intake were categorized into quartiles. The outcome of interest was impairment on the Six-Item Screener (SIS), a measure of global cognitive functioning administered annually. The Enhanced Cognitive Battery (ECB), a more comprehensive series of tests assessing memory and fluency, was administered every two years and considered a secondary outcome. Associations between zinc and incident impairment were assessed using multivariable logistic regression.

resultsAmong 2065 participants with serum zinc data, 184 individuals developed impairment over 10 years of follow-up. In adjusted models, there was no significant association between serum zinc and impairment as assessed by the SIS or the ECB. Among 18,103 participants who had dietary data, 1424 experienced incident impairment on the SIS. Dietary zinc intake was not significantly associated with impairment as assessed by the SIS or the ECB in adjusted models.

conclusionFindings from this U.S. cohort did not support the hypothesis that serum zinc concentration or dietary zinc intake is associated with the risk of cognitive impairment.

Indexed as

CognitionDietZincAgedCognitive DysfunctionCohort StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsStrokeUnited StatesZincCognitive impairmentDietSerumZinc

Identifiers

PMID38294520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.