Evidence map›Paper›PMID 38294237›Full record

ArticlemBio2024

Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant

Gregory A Harrison, Erin R Wang, Kevin Cho, Yassin Mreyoud, Souvik Sarkar, Fredrik Almqvist, Gary J Patti, Christina L Stallings

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Metabolic rewiring of isoniazid sensitivity inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Gregory A HarrisonDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-6050-1312
Erin R WangDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Kevin ChoDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA.
Yassin MreyoudDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.
Souvik SarkarDepartment of Chemistry, Umeå University, Umeå, Sweden.
Fredrik AlmqvistDepartment of Chemistry, Umeå University, Umeå, Sweden.
Gary J PattiDepartment of Chemistry, Washington University in St. Louis, St. Louis, Missouri, USA.
Christina L StallingsDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-2747-5618
Washington University in St. Louis · USUmeå University · SE

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
Developing Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9M
Chemical disarming of drug resistance in Mycobacterium tuberculosisR01AI134847 · NIAID · WASHINGTON UNIVERSITY · PI ALMQVIST, FREDRIK, STALLINGS, CHRISTINA LEIGH · 2018 to 2021
$2.7M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI134847NIAID NIH HHS T32 AI007172NIEHS NIH HHS R35 ES028365
6 · The paper itself

Abstract

Of the approximately 10 million cases of

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsBacterial ProteinsCatalaseDrug Resistance, BacterialHumansIsoniazidMicrobial Sensitivity TestsMutationAntitubercular AgentsBacterial ProteinsCatalaseIsoniazidantibiotic resistanceisoniazidKatGMycobacterium tuberculosismycolic acids

Identifiers

PMID38294237
PMCPMC10936210
OpenAlexW4391386588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.