Evidence map›Paper›PMID 38294229›Full record

ArticlemSystems2024

Utilization of nanopore direct RNA sequencing to analyze viral RNA modifications.

Lu Tan, Zhihao Guo, Xiaoming Wang, Dal Young Kim, Runsheng Li

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. The respiratory tract virome: unravelling the role of viral dark matter in respiratory health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  10. Article
  11. Nanopore sequencing in veterinary medicine: from concepts to clinical applications.Frontiers in cellular and infection microbiology · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lu Tan *Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China.ORCID 0000-0002-6685-0468
Zhihao Guo *Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China.ORCID 0000-0001-8315-5152
Xiaoming WangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Dal Young KimDepartment of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China.ORCID 0000-0003-1756-3128
Runsheng LiDepartment of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China.ORCID 0000-0003-1563-1844
City University of Hong Kong · HKNanjing Agricultural University · CN

Funding

City University of Hong Kong (CityU) 9610497City University of Hong Kong (CityU) 9676013, 9610451GDSTC | Natural Science Foundation of Guangdong Province () 9240054Hong Kong Health and Medical Research Fund 08194126Research Grants Council, University Grants Committee () CityU 21100521
6 · The paper itself

Abstract

Modifications on viral RNAs (vRNAs), either genomic RNAs or RNA transcripts, have complex effects on the viral life cycle and cellular responses to viral infection. The advent of Oxford Nanopore Technologies Direct RNA Sequencing provides a new strategy for studying RNA modifications. To this end, multiple computational tools have been developed, but a systemic evaluation of their performance in mapping vRNA modifications is lacking. Here, 10 computational tools were tested using the Sindbis virus (SINV) RNAs isolated from infected mammalian (BHK-21) or mosquito (C6/36) cells, with

Indexed as

NanoporesSindbis VirusAnimalsCell LineMammalsRNA, ViralSequence Analysis, RNARNA, Viralalphaviruscomparative methodsnanoporeRNA modificationSindbis virus

Identifiers

PMID38294229
PMCPMC10878088
OpenAlexW4391403226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.