Evidence map›Paper›PMID 38294131›Full record

ArticleAdvanced healthcare materials2024

A Cellulose/Chitosan Dual Cross-Linked Multifunctional and Resilient Hydrogel for Emergent Open Wound Management.

Shengchang Lu, Hui Wu, Shengbo Ge, Liulian Huang, Lihui Chen, Chris Connor, Zhanhu Guo, Yunhong Jiang, Ben Bin Xu, Wanxi Peng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
29.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Shengchang LuSchool of Forestry, Henan Agricultural University, Zhengzhou, 450002, P. R. China.
Hui WuCollege of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, P. R. China.
Shengbo GeCo-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, 210037, P. R. China.
Liulian HuangCollege of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, P. R. China.
Lihui ChenCollege of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, P. R. China.
Chris ConnorMechanical and Construction Engineering, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK.
Zhanhu GuoMechanical and Construction Engineering, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK.
Yunhong JiangHub for Biotechnology in the Built Environment, Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.
Ben Bin XuMechanical and Construction Engineering, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK.ORCID 0000-0002-6747-2016
Wanxi PengSchool of Forestry, Henan Agricultural University, Zhengzhou, 450002, P. R. China.
Northumbria University · GBState Forestry and Grassland Administration · CNHenan Agricultural University · CNNanjing Forestry University · CN

Funding

China Postdoctoral Science Foundation 2022M721038Engineering and Physical Sciences Research Council EP/N007921Engineering and Physical Sciences Research Council EPSRC UKEngineering and Physical Sciences Research Council EP/X02041X. Y.H.JNational Natural Science Foundation of China 22278071
6 · The paper itself

Abstract

Adhesive hydrogel holds huge potential in biomedical applications, such as hemostasis and emergent wound management during outpatient treatment or surgery. However, most adhesive hydrogels underperform to offer robust adhesions on the wet tissue, increasing the risk of hemorrhage and reducing the fault tolerance of surgery. To address this issue, this work develops a polysaccharide-based bioadhesive hydrogel tape (ACAN) consisting of dual cross-linking of allyl cellulose (AC) and carboxymethyl chitosan (CMCS). The hygroscopicity of AC and CMCS networks enables ACAN to remove interfacial water from the tissue surface and initializes a physical cross-link instantly. Subsequently, covalent cross-links are developed with amine moieties to sustain long-term and robust adhesion. The dual cross-linked ACAN also has good cytocompatibility with controllable mechanical properties matching to the tissue, where the addition of CMCS provides remarkable antibacterial properties and hemostatic capability. Moreover, compared with commercially available 3 M film, ACAN provides an ultrafast wound healing on tissue. The ACAN hybrid hydrogels have advantages such as biocompatibility and antibacterial, hemostatic, and wound healing properties, shedding new light on first-aid tape design and advancing the cellulose-based materials technology for high-performance biomedical applications.

Indexed as

CelluloseChitosanHydrogelsWound HealingAnimalsAnti-Bacterial AgentsBiocompatible MaterialsCross-Linking ReagentsHemostaticsHumansMiceAnti-Bacterial AgentsBiocompatible Materialscarboxymethyl-chitosanCelluloseChitosanCross-Linking ReagentsHemostaticsHydrogelsadhesivecellulosechitosanfirst‐aid tapehybrid hydrogel

Identifiers

PMID38294131
PMCPMC11468647
OpenAlexW4391387848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.