Evidence map›Paper›PMID 38293983›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Exosomes from ectoderm mesenchymal stem cells inhibits lipopolysaccharide-induced microglial M1 polarization and promotes survival of H

X Sun, H Shi, L Zhang, Z Liu, K Li, L Qian, X Zhu, K Yang, Q Fu, H Ding

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

X SunDepartment of Orthopedics, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
H ShiDepartment of Orthopedics, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
L ZhangDepartment of Orthopedics, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
Z LiuDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
K LiDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
L QianSchool of Medicine, Jiangsu University, Zhenjiang 212013, China.
X ZhuDepartment of Orthopedics, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
K YangDepartment of Orthopedics, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
Q FuDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
H DingDepartment of Orthopedics, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, China.
Shanghai First People's Hospital · CNJiangsu University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the potential value of exosomes derived from rat ectoderm mesenchymal stem cells (EMSCs-exo) for repairing secondary spinal cord injury.

methodsEMSCs-exo were obtained using ultracentrifugation from EMSCs isolated from rat nasal mucosa, identified by transmission electron microscope, nanoparticle tracking analysis (NTA), and Western blotting, and quantified using the BCA method. Neonatal rat microglia purified by differential attachment were induced with 100 μg/L lipopolysaccharide (LPS) and treated with 37.5 or 75 mg/L EMSCs-exo. PC12 cells were exposed to 400 μmol/L H

resultsThe isolated rat EMSCs showed high expressions of nestin, CD44, CD105, and vimentin. The obtained EMSCs-exo had a typical cup-shaped structure under transmission electron microscope with an average particle size of 142 nm and positivity for CD63, CD81, and TSG101 but not vimentin. In LPS-treated microglia, EMSCs-exo treatment at 75 mg/L significantly increased Arg1 protein level and lowered iNOS protein expression (

conclusionEMSCs-exo at 75 mg/L can effectively reduce the proportion of M1 microglia and alleviate neuronal apoptosis under oxidative stress to promote neuronal survival, suggesting its potential in controlling secondary spinal cord injury.

Indexed as

ExosomesMesenchymal Stem CellsSpinal Cord InjuriesAnimalsEctodermHydrogen PeroxideInsulin-Like Growth Factor IInterleukin-10LipopolysaccharidesMicrogliaOxidative StressPC12 CellsRatsRNA, MessengerHydrogen PeroxideInsulin-Like Growth Factor IInterleukin-10LipopolysaccharidesRNA, Messengerectoderm mesenchymal stem cellsexosomesinflammationmicrogliaoxidative stresssecondary spinal cord injury

Identifiers

PMID38293983
PMCPMC10878899
OpenAlexW4394763208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.