Evidence map›Paper›PMID 38293977›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Platycodin D improves pulmonary fibrosis in mice by down-regulating TRPC6 expression and reducing ROS production in lung fibroblasts].

Z Liang, C Yu, S Liang, Z Zhou, Z Zhou, X Meng, F Zou, S Cai

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Z LiangDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
C YuDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
S LiangDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z ZhouDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Z ZhouDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
X MengSchool of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China.
F ZouSchool of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China.
S CaiDepartment of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Southern Medical University · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the effect of platycodin D (PD) for alleviating pulmonary fibrosis in mice and explore the underlying mechanism.

methodsC57BL/6J mouse models of pulmonary fibrosis induced by bleomycin injection into the airway were treated with daily intragastric administration of 10 mg/kg PD for 28 days. The changes of pulmonary fibrosis and the expression and distribution of transient receptor potential cation channel subfamily C member 6 (TRPC6) were evaluated with immunohistochemistry, HE staining and Sirius Red staining. Western blotting was used to detect

resultsPD treatment significantly alleviated pulmonary fibrosis and reduced

conclusionPD alleviated pulmonary fibrosis in mice possibly by down-regulating TRPC6 and reducing ROS production.

Indexed as

Pulmonary FibrosisSaponinsTriterpenesAnimalsBleomycinCollagen Type IFibroblastsLungMiceMice, Inbred C57BLReactive Oxygen SpeciesTransforming Growth Factor beta1TRPC6 Cation ChannelBleomycinCollagen Type Iplatycodin DReactive Oxygen SpeciesSaponinsTransforming Growth Factor beta1TriterpenesTRPC6 Cation Channelplatycodin Dpulmonary fibrosisreactive oxygen speciestransient receptor potential cation channel subfamily C member 6

Identifiers

PMID38293977
PMCPMC10878886
OpenAlexW4394767031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.