Evidence map›Paper›PMID 38293946›Full record

ArticleJournal of the American Heart Association2024

Noninvasive Advanced Cardiovascular Magnetic Resonance-Derived Fontan Hemodynamics Are Associated With Reduced Kidney Function But Not Albuminuria.

Jef Van den Eynde, Jos J M Westenberg, Mark G Hazekamp, Hildo J Lamb, Monique R M Jongbloed, Jolanda J Wentzel, Sasa Kenjeres, Ilona A Dekkers, Alexander Van De Bruaene, Friso M Rijnberg and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Biomechanics and clinical implications of Fontan upsizing.Computers in biology and medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jef Van den EyndeDepartment of Pediatrics, Division of Pediatric Cardiology Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0002-5606-376X
Jos J M WestenbergCardioVascular Imaging Group, Department of Radiology Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0003-1946-1715
Mark G HazekampDepartment of Cardiothoracic Surgery Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0002-3150-5007
Hildo J LambCardioVascular Imaging Group, Department of Radiology Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0002-6969-2418
Monique R M JongbloedDepartment of Cardiology Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0002-9132-0418
Jolanda J WentzelDepartment of Cardiology Biomechanical Engineering, Erasmus MC Rotterdam The Netherlands.ORCID 0000-0001-9893-3404
Sasa KenjeresDepartment of Chemical Engineering, Faculty of Applied Sciences Delft University of Technology Delft The Netherlands.ORCID 0000-0002-7568-5513
Ilona A DekkersCardioVascular Imaging Group, Department of Radiology Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0002-3329-0660
Alexander Van De BruaeneCongenital and Structural Cardiology University Hospitals Leuven Leuven Belgium.ORCID 0000-0002-0469-8640
Friso M RijnbergDepartment of Cardiothoracic Surgery Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0003-1804-3220
Arno A W RoestDepartment of Pediatrics, Division of Pediatric Cardiology Leiden University Medical Center Leiden The Netherlands.ORCID 0000-0002-0153-5934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney disease is the most important predictor of death in patients with a Fontan circulation, yet its clinical and hemodynamic correlates have not been well established. METHODS AND

resultsA total of 53 ambulatory patients with a Fontan circulation (median age, 16.2 years, 52.8% male patients) underwent advanced cardiovascular magnetic resonance assessment, including 4-dimensional flow imaging and computational fluid dynamics. Estimated glomerular filtration rate (eGFR) <90 mL/min per 1.73 m

conclusionsKidney dysfunction and albuminuria are common among clinically well adolescents and young adults with a Fontan circulation. Advanced cardiovascular magnetic resonance-derived metrics indicative of declining Fontan hemodynamics are associated with eGFR and might serve as targets to improve kidney health. Albuminuria might be driven by other factors that need further investigation.

Indexed as

Fontan ProcedureHeart Defects, CongenitalAdolescentAlbuminsAlbuminuriaCreatinineFemaleHemodynamicsHumansKidneyMagnetic Resonance SpectroscopyMaleYoung AdultAlbuminsCreatininealbuminuriachronic kidney diseasecomputational fluid dynamicsFontanhemodynamicskidney functionmagnetic resonance imaging

Identifiers

PMID38293946
PMCPMC11056124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.