Evidence map›Paper›PMID 38293836›Full record

ArticleJournal of psychopharmacology (Oxford, England)2024

Role of α1-GABA

Chen Li, Bryan D McElroy, Jared Phillips, Nicholas S McCloskey, Xiangdang Shi, Ellen M Unterwald, Lynn G Kirby

Open access · greenAbstract read
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chen LiCenter for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.ORCID 0009-0001-0671-3904
Bryan D McElroyCenter for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Jared PhillipsDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville TN, USA.ORCID 0000-0001-5809-970X
Nicholas S McCloskeyCenter for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Xiangdang ShiCenter for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Ellen M UnterwaldCenter for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Lynn G KirbyCenter for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Temple University · USVanderbilt University · US

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI SCOTT M. RAWLS · 2000 to 2026
$34.6M
TRAINING PROGRAM: DRUGS OF ABUSE RELATED NEUROPEPTIDEST32DA007237 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLEN M UNTERWALD · 1988 to 2026
$10.6M
Regulation of 5-HT circuits by CRF and GABA in opioid addiction and stress-induced relapseR01DA045771 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KIRBY, LYNN G · 2019 to 2023
$1.9M
GABAergic Sensitization of the Serotonin System in Stress-Induced Opiate RelapseR21DA037523 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI KIRBY, LYNN G · 2014 to 2015
$426k
NIDA NIH HHS P30 DA013429NIDA NIH HHS R01 DA045771NIDA NIH HHS R21 DA037523NIDA NIH HHS T32 DA007237
6 · The paper itself

Abstract

backgroundThe serotonin (5-hydroxytryptamine (5-HT))-mediated system plays an important role in stress-related psychiatric disorders and substance abuse. Our previous studies showed that stress and drug exposure can modulate the dorsal raphe nucleus (DRN)-5-HT system via γ-aminobutyric acid (GABA) AIM/

methodsTo further test the role of GABA

resultsOur results showed that mice with DRN-specific knockout of α1-GABA

conclusionsOur data suggest that GABA

Indexed as

Analgesics, OpioidDorsal Raphe NucleusAnimalsAnxietyDepressiongamma-Aminobutyric AcidHumansMiceMorphineRatsRats, Sprague-DawleySerotonergic NeuronsSerotoninAnalgesics, Opioidgamma-Aminobutyric AcidMorphineSerotoninanxietydepressiondorsal rapheopioidα1-GABAA

Identifiers

PMID38293836
PMCPMC10921389
OpenAlexW4391401560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.