Evidence map›Paper›PMID 38293753›Full record

ArticleLeukemia & lymphoma2024

Real-world evidence of obinutuzumab and venetoclax in previously treated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

Matthew M Lei, Mark N Sorial, Uvette Lou, Michelle Yu, Andrea Medrano, Josie Ford, Ronald A Nemec, Jeremy S Abramson, Jacob D Soumerai

Open access · greenAbstract read
In one paragraph

Article in Leukemia & lymphoma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Management of Relapsed and/or Refractory Chronic Lymphocytic Leukemia.Hematology/oncology clinics of North America · 2025
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Matthew M LeiDepartment of Pharmacy, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-5348-6065
Mark N SorialDepartment of Pharmacy, Massachusetts General Hospital, Boston, MA, USA.
Uvette LouDepartment of Pharmacy, Massachusetts General Hospital, Boston, MA, USA.
Michelle YuSchool of Pharmacy, Northeastern University, Boston, MA, USA.
Andrea MedranoSchool of Pharmacy, Northeastern University, Boston, MA, USA.
Josie FordCenter for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA.ORCID 0009-0004-7612-3258
Ronald A NemecCenter for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Jeremy S AbramsonCenter for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA.ORCID 0000-0001-8467-9257
Jacob D SoumeraiCenter for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA, USA.ORCID 0000-0002-3062-6819
Massachusetts General Hospital · USNortheastern University · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Predictive markers for personalized therapy in chronic lymphocytic leukemiaK08CA270202 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Jacob Soumerai · 2023 to 2026
$1.1M
NCATS NIH HHS UL1 TR002541NCI NIH HHS K08 CA270202
6 · The paper itself

Abstract

Venetoclax-obinutuzumab (Ven-O) is frequently administered off-label in relapsed/refractory (r/r) CLL/SLL where venetoclax-rituximab is the approved regimen. We conducted this retrospective, real-world study to evaluate Ven-O in r/r CLL/SLL. Between 7/2019 and 6/2022, 40 patients with r/r CLL/SLL on Ven-O were included. The median age was 72, 28.2% had

Indexed as

Antibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsBridged Bicyclo Compounds, HeterocyclicLeukemia, Lymphocytic, Chronic, B-CellSulfonamidesAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAntibodies, Monoclonal, HumanizedBridged Bicyclo Compounds, HeterocyclicobinutuzumabSulfonamidesvenetoclaxCLL/SLL (or chronic lymphocytic leukemia/small lymphocytic lymphoma)obinutuzumabrefractoryrelapsedvenetoclax

Identifiers

PMID38293753
PMCPMC11097209
OpenAlexW4391389418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.