Evidence map›Paper›PMID 38293554›Full record

ArticleFrontiers in microbiology2023

Identification of taxonomic changes in the fecal bacteriome associated with colorectal polyps and cancer: potential biomarkers for early diagnosis.

Beatriz Alessandra Rudi Grion, Paula Luize Camargos Fonseca, Rodrigo Bentes Kato, Glen Jasper Yupanqui García, Aline Bruna Martins Vaz, Beatriz Nafría Jiménez, Ainhoa Lapitz Dambolenea, Koldo Garcia-Etxebarria, Bertram Brenig, Vasco Azevedo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Review
  6. Article
  7. [Review of application of U-Net and Transformer in colon polyp image segmentation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  8. Review
  9. Article
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  12. Dysbiosis and colonic adenoma: The lethal link?World journal of clinical oncology · 2024
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Beatriz Alessandra Rudi GrionLaboratory of Molecular and Computational Biology of Fungi, Institute of Biological Sciences, Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Paula Luize Camargos FonsecaIntegrative Biology Laboratory, Institute of Biological Sciences, Department of Genetics, Ecology, and Evolution, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Rodrigo Bentes KatoPublic Health Laboratories, Ministry of Health, Brasília, Brazil.
Glen Jasper Yupanqui GarcíaGraduate Program in Bioinformatics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Aline Bruna Martins VazOswaldo Cruz Foundation (Fiocruz-MG), Minas Gerais, Brazil.
Beatriz Nafría JiménezDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, Ikerbasque, San Sebastian, Spain.
Ainhoa Lapitz DamboleneaDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, Ikerbasque, San Sebastian, Spain.
Koldo Garcia-EtxebarriaDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, Ikerbasque, San Sebastian, Spain.
Bertram BrenigInstitute of Veterinary Medicine, Burckhardtweg, University of Göttingen, Göttingen, Germany.
Vasco AzevedoLaboratory of Cellular and Molecular Genetics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Luis BujandaDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, Ikerbasque, San Sebastian, Spain.
Jesus M BanalesDepartment of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital, Ikerbasque, San Sebastian, Spain.
Aristóteles Góes-NetoLaboratory of Molecular and Computational Biology of Fungi, Institute of Biological Sciences, Department of Microbiology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRBiogipuzkoa Health Research Institute · ESCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESFundação Oswaldo Cruz · BRIkerbasque · ESMinistério da Saúde · BRUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) commonly arises in individuals with premalignant colon lesions known as polyps, with both conditions being influenced by gut microbiota. Host-related factors and inherent characteristics of polyps and tumors may contribute to microbiome variability, potentially acting as confounding factors in the discovery of taxonomic biomarkers for both conditions. In this study we employed shotgun metagenomics to analyze the taxonomic diversity of bacteria present in fecal samples of 90 clinical subjects (comprising 30 CRC patients, 30 with polyps and 30 controls). Our findings revealed a decrease in taxonomic richness among individuals with polyps and CRC, with significant dissimilarities observed among the study groups. We identified significant alterations in the abundance of specific taxa associated with polyps (Streptococcaceae,

Indexed as

bacteriomebiomarkerscolorectal cancergut microbiomemetagenomics

Identifiers

PMID38293554
PMCPMC10827328
OpenAlexW4390745249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.