Evidence map›Paper›PMID 38293542›Full record

ArticleHeliyon2024

Association between dysbiotic perio-pathogens and inflammatory initiators and mediators in COVID-19 patients with diabetes.

Endang W Bachtiar, Boy M Bachtiar, Ardiana Kusumaningrum, Hari Sunarto, Yuniarti Soeroso, Benso Sulijaya, Citra Fragrantia Theodorea, Irandi Putra Pratomo, Yudhistira, Defi Efendi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Endang W BachtiarDepartment of Oral Biology, Faculty of Dentistry Universitas Indonesia, Indonesia.
Boy M BachtiarDepartment of Oral Biology, Faculty of Dentistry Universitas Indonesia, Indonesia.
Ardiana KusumaningrumDepartment of Microbiology, Faculty of Medicine, Universitas Indonesia, Clinical Microbiology Medicine Staff Group, Universitas Indonesia Hospital, Indonesia.
Hari SunartoDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Indonesia.
Yuniarti SoerosoDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Indonesia.
Benso SulijayaDepartment of Periodontology, Faculty of Dentistry, Universitas Indonesia, Indonesia.
Citra Fragrantia TheodoreaDepartment of Oral Biology, Faculty of Dentistry Universitas Indonesia, Indonesia.
Irandi Putra PratomoDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia.
YudhistiraClinical Pathology Medicine Staff Group, Universitas Indonesia Hospital, Indonesia.
Defi EfendiDepartment of Pediatric Nursing, Faculty of Nursing Universitas Indonesia, and Neonatal Intensive Care Unit, Universitas Indonesia Hospital, Depok, Indonesia.
Efa ApriyantiDepartment of Pediatric Nursing, Faculty of Nursing Universitas Indonesia, and Paediatric Intensive Care Unit, Universitas Indonesia Hospital, Indonesia.
Shahida Mohd SaidDepartment of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia.
University of Indonesia · IDNational University of Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been suggested that a corona virus infection is linked to chronic periodontitis (COVID-19). Our objectives were to look at the expression of angiotensin-converting enzyme-2 (ACE2) in periodontal compartments containing periodontal infections to determine if ACE2 is directly or indirectly responsible for the inflammation in periodontal tissues getting worse. In this study, six non-COVID-19 periodontitis patients without diabetes served as controls, and 23 hospitalized periodontitis patients were admitted with PCR-confirmed COVID-19 with diabetes mellitus (Group 1/G1, n = 10), and without diabetes (Group 2/G2, n = 13). We evaluated the mRNA expression of ACE2, IL-6, IL-8, complement C3, and LL-37, as well as the relative proportion of

Indexed as

ACE2Corona virusDiabetesDysbiosisGingival crevicular fluidInflammationmRNA expressionPeriodontitis

Identifiers

PMID38293542
PMCPMC10825424
OpenAlexW4390635913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.