Evidence map›Paper›PMID 38293277›Full record

ArticleTherapeutic advances in medical oncology2024

The role of aberrant DNA methylation in cancer initiation and clinical impacts.

Franziska Geissler, Ksenija Nesic, Olga Kondrashova, Alexander Dobrovic, Elizabeth M Swisher, Clare L Scott, Matthew J Wakefield

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 79 citations in OpenAlex.

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  16. Prevalence ofJCO precision oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Franziska GeisslerWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID https://orcid.org/0000-0003-3568-2008
Ksenija NesicWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID https://orcid.org/0000-0001-9972-9819
Olga KondrashovaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Alexander DobrovicUniversity of Melbourne Department of Surgery, Austin Health, Heidelberg, VIC, Australia.
Elizabeth M SwisherUniversity of Washington, Seattle, WA, USA.
Clare L ScottWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Matthew J WakefieldWalter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC, Australia.ORCID https://orcid.org/0000-0001-6624-4698
The University of Melbourne · AUQIMR Berghofer Medical Research Institute · AUThe Royal Melbourne Hospital · AUUniversity of Washington · USWalter and Eliza Hall Institute of Medical Research · AU

Funding

Combined Methylation and Mutation to Predict Response to PARP InhibitorsR01CA237600 · NCI · UNIVERSITY OF WASHINGTON · PI SWISHER, ELIZABETH MARY · 2020 to 2024
$2.9M
Methylation and Mutation Assay to Personalize PARP Inhibitor TherapyR01CA251817 · NCI · UNIVERSITY OF WASHINGTON · PI SWISHER, ELIZABETH MARY · 2020 to 2022
$1.4M
NCI NIH HHS R01 CA237600NCI NIH HHS R01 CA251817
6 · The paper itself

Abstract

Epigenetic alterations, including aberrant DNA methylation, are now recognized as

Indexed as

BRCA-related cancersdiagnosisepigenomicsgenomicsgenomic testinghomologous recombination deficiencyoncogenic driver mutationstargeted therapytherapeutic resistance

Identifiers

PMID38293277
PMCPMC10826407
OpenAlexW4391325299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.