Evidence map›Paper›PMID 38293242›Full record

ArticlebioRxiv : the preprint server for biology2025

Navigating contradictions:

Kailie Franco, Zealon Gentry-Lear, Michael Shavlik, Michael J Harms, Arden Baylink

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kailie FrancoDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.ORCID 0000-0003-4719-225X
Zealon Gentry-LearInstitute of Molecular Biology, University of Oregon, Eugene, Oregon, USA.ORCID 0000-0002-0350-7494
Michael ShavlikDepartment of Chemistry & Biochemistry, University of Oregon, Eugene, Oregon, USA.ORCID 0000-0002-0395-8578
Michael J HarmsInstitute of Molecular Biology, University of Oregon, Eugene, Oregon, USA.ORCID 0000-0002-0241-4122
Arden BaylinkDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.ORCID 0000-0001-5522-769X

Funding

Understanding the molecular mechanisms and biological functions of a novel bleach-sensing bacterial receptor in shaping host-associated bacterial populations in response to host inflammationR00AI148587 · NIAID · WASHINGTON STATE UNIVERSITY · PI BAYLINK, ARDEN · 2022 to 2023
$498k
Understanding the molecular mechanisms and biological functions of a novel bleach-sensing bacterial receptor in shaping host-associated bacterial populations in response to host inflammationK99AI148587 · NIAID · UNIVERSITY OF OREGON · PI BAYLINK, ARDEN · 2020 to 2021
$235k
NIAID NIH HHS K99 AI148587NIAID NIH HHS R00 AI148587
6 · The paper itself

Abstract

Motile bacteria sense and avoid deleterious stimuli in their environment through chemorepulsion, a behavior that helps them locate permissive ecological niches. In the gut, indole is a bacteriostatic compound produced by the microbiota and is thought to act as a chemorepellent for invading pathogens, thereby protecting the host against infection. The principal reservoir of intestinal indole is fecal matter, a complex biological material that contains both attractant and repellent stimuli. Whether indole in its natural context is sufficient for pathogen chemorepulsion or host protection has remained unknown. Using an intestinal explant system, we show that while pure indole indeed suppresses an infection advantage mediated through chemotaxis for the enteric pathogen

Identifiers

PMID38293242
PMCPMC10827161

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.