Evidence map›Paper›PMID 38293241›Full record

ArticlebioRxiv : the preprint server for biology2024

Opioid-driven disruption of the septal complex reveals a role for neurotensin-expressing neurons in withdrawal.

Rhiana C Simon, Weston T Fleming, Pranav Senthilkumar, Brandy A Briones, Kentaro K Ishii, Madelyn M Hjort, Madison M Martin, Koichi Hashikawa, Andrea D Sanders, Sam A Golden and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rhiana C SimonCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Weston T FlemingCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Pranav SenthilkumarCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Brandy A BrionesCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Kentaro K IshiiCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Madelyn M HjortCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Madison M MartinCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Koichi HashikawaCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Andrea D SandersCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Sam A GoldenCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.
Garret D StuberCenter for the Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0003-1730-4855

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0M
Neural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5M
Lateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0M
The impact of early life opioid exposure on the molecular and functional trajectories of septal cell typesR01DA059388 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COREY C HARWELL, Garret D Stuber · 2023 to 2026
$3.1M
Disentangling stress-induced transcriptional and functional heterogeneity of the midbrainF31MH117931 · NIMH · UNIVERSITY OF WASHINGTON · PI SIMON, RHIANA CATHERINE · 2019 to 2021
$122k
NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA038168NIDA NIH HHS R01 DA059388NIDA NIH HHS R37 DA032750NIMH NIH HHS F31 MH117931
6 · The paper itself

Abstract

Because opioid withdrawal is an intensely aversive experience, persons with opioid use disorder (OUD) often relapse to avoid it. The lateral septum (LS) is a forebrain structure that is important in aversion processing, and previous studies have linked the lateral septum (LS) to substance use disorders. It is unclear, however, which precise LS cell types might contribute to the maladaptive state of withdrawal. To address this, we used single-nucleus RNA-sequencing to interrogate cell type specific gene expression changes induced by chronic morphine and withdrawal. We discovered that morphine globally disrupted the transcriptional profile of LS cell types, but Neurotensin-expressing neurons (

Identifiers

PMID38293241
PMCPMC10827099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.