Evidence map›Paper›PMID 38293170›Full record

ArticlebioRxiv : the preprint server for biology2024

An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries.

Brian M Petersen, Monica B Kirby, Karson M Chrispens, Olivia M Irvin, Isabell K Strawn, Cyrus M Haas, Alexis M Walker, Zachary T Baumer, Sophia A Ulmer, Edgardo Ayala and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Brian M PetersenDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Monica B KirbyDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Karson M ChrispensDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Olivia M IrvinDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Isabell K StrawnDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Cyrus M HaasDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Alexis M WalkerDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Zachary T BaumerDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Sophia A UlmerDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Edgardo AyalaDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Emily R RhodesDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Jenna J GuthmillerDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Paul J SteinerDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.
Timothy A WhiteheadDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80305, USA.

Funding

The influence of evolutionary landscapes on protective antibody developmentR01AI141452 · NIAID · UNIVERSITY OF COLORADO · PI WHITEHEAD, TIMOTHY ANDREW · 2019 to 2023
$2.8M
Investigating the development and clonal dynamics of broadly neutralizing B cells against influenza virusesR00AI159136 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GUTHMILLER, JENNA · 2022 to 2022
$249k
NIAID NIH HHS R00 AI159136NIAID NIH HHS R01 AI141452
6 · The paper itself

Abstract

Antibodies are engineerable quantities in medicine. Learning antibody molecular recognition would enable the

Identifiers

PMID38293170
PMCPMC10827193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.