Evidence map›Paper›PMID 38293134›Full record

ArticlebioRxiv : the preprint server for biology2024

Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape.

B Santinello, R Sun, A Amjad, S J Hoyt, L Ouyang, C Courret, R Drennan, L Leo, A M Larracuente, L Core and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

B Santinello
R Sun
A Amjad
S J HoytORCID 0000-0001-7804-3236
L Ouyang
C Courret
R Drennan
L Leo
A M LarracuenteORCID 0000-0001-5944-5686
L CoreORCID 0000-0002-1698-1144
R J O'NeillORCID 0000-0002-1525-6821
B G MelloneORCID 0000-0002-2785-5119
University of Connecticut · USUniversity of Rochester · US

Funding

Genetic and Epigenetic Determinants of Centromere IdentityR35GM131868 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI BARBARA MELLONE · 2019 to 2026
$3.1M
Regulation, evolution, and function of promoter-associated non-coding RNAsR35GM128857 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI CORE, LEIGHTON JAMES · 2018 to 2022
$2.0M
The Role of Retroelements in Centromere FunctionR01GM123312 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI O'NEILL, RACHEL · 2019 to 2022
$1.9M
NIGMS NIH HHS R01 GM123312NIGMS NIH HHS R35 GM128857NIGMS NIH HHS R35 GM131868
6 · The paper itself

Abstract

Centromeres depend on chromatin containing the conserved histone H3 variant CENP-A for function and inheritance, while the role of centromeric DNA repeats remains unclear. Retroelements are prevalent at centromeres across taxa and represent a potential mechanism for promoting transcription to aid in CENP-A incorporation or for generating RNA transcripts to maintain centromere integrity. Here, we probe into the transcription and RNA localization of the centromere-enriched retroelement

Identifiers

PMID38293134
PMCPMC10827089
OpenAlexW4390876014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.