ArticlebioRxiv : the preprint server for biology2024
MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth.
Olivia J Cheng, Eric J Lebish, Owen Jensen, Damian Jacenik, Shubhanshi Trivedi, Jackson Cacioppo, Jeffrey Aubé, Ellen J Beswick, Daniel T Leung
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 2 countries.
Olivia J ChengDivision of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, United States.
Eric J LebishDivision of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
Owen JensenDivision of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, United States.
Damian JacenikDivision of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
Shubhanshi TrivediDivision of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-6891-2290 Jackson CacioppoDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Jeffrey AubéDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Ellen J BeswickDivision of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
Daniel T LeungDivision of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-8401-0801 University of Utah · USUniversity of North Carolina at Chapel Hill · USUniversity of Kentucky · US
Funding
Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccinationR01AI130378 · NIAID · UNIVERSITY OF UTAH · PI LEUNG, DANIEL TED · 2017 to 2021
$1.8MG-CSF inhibition as a colorectal cancer therapyR01CA207051 · NCI · UNIVERSITY OF UTAH · PI BESWICK, ELLEN J. · 2016 to 2021
$1.7MMentoring patient-oriented researchers in pediatric diarrheaK24AI166087 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Daniel Ted Leung · 2023 to 2026
$688kNCI NIH HHS R01 CA207051NIAID NIH HHS K24 AI166087NIAID NIH HHS R01 AI130378
6 · The paper itselfAbstract
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon. MAIT cells have cytotoxic and pro-inflammatory functions and have potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, including their role in colon cancer, are limited. Using an animal model of colon cancer, we show that peritumoral injection of
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PMID38293128
PMCPMC10827136
OpenAlexW4391050534
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