Evidence map›Paper›PMID 38293114›Full record

ArticlebioRxiv : the preprint server for biology2025

The blobulator: a toolkit for identification and visual exploration of hydrophobic modularity in protein sequences.

Connor Pitman, Ezry Santiago-McRae, Ruchi Lohia, Ryan Lamb, Kaitlin Bassi, Lindsey Riggs, Thomas T Joseph, Matthew E B Hansen, Grace Brannigan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Connor PitmanCenter for Computational and Integrative Biology, Rutgers University-Camden, 201 Broadway, 08103, NJ, USA.
Ezry Santiago-McRaeCenter for Computational and Integrative Biology, Rutgers University-Camden, 201 Broadway, 08103, NJ, USA.
Ruchi LohiaDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, 19104, PA, USA.ORCID 0000-0002-3496-8197
Ryan LambCenter for Computational and Integrative Biology, Rutgers University-Camden, 201 Broadway, 08103, NJ, USA.
Kaitlin BassiCenter for Computational and Integrative Biology, Rutgers University-Camden, 201 Broadway, 08103, NJ, USA.
Lindsey RiggsCenter for Computational and Integrative Biology, Rutgers University-Camden, 201 Broadway, 08103, NJ, USA.
Thomas T JosephDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, JMB 305, 3620 Hamilton Walk, 19104, PA, USA.
Matthew E B HansenDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, 19104, PA, USA.
Grace BranniganCenter for Computational and Integrative Biology, Rutgers University-Camden, 201 Broadway, 08103, NJ, USA.

Funding

Integrative Genomic Analyses of Human Evolution and Adaptation in AfricaR35GM134957 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2020 to 2024
$2.7M
Efficient prediction of transmembrane binding sites for anesthetic ligandsK08GM139031 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI JOSEPH, THOMAS THENGANPALLIL · 2020 to 2024
$984k
NIGMS NIH HHS K08 GM139031NIGMS NIH HHS R35 GM134957
6 · The paper itself

Abstract

While contiguous subsequences of hydrophobic residues are essential to protein structure and function, as in the hydrophobic core and transmembrane regions, there are no current bioinformatics tools for module identification focused on hydrophobicity. To fill this gap, we created the

Indexed as

computational methodshydrophobicityintrinsically disordered proteinsprotein sequence organizationsequence-structure relationshipsingle nucleotide polymorphism

Identifiers

PMID38293114
PMCPMC10827107

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.