Evidence map›Paper›PMID 38293058›Full record

ArticlebioRxiv : the preprint server for biology2024

Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture.

Pradeep Kumar Singh, Elisa Nicoloso Simoes Pires, Zu-Lin Chen, Daniel Torrente, Marissa Calvano, Anurag Sharma, Sidney Strickland, Erin H Norris

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Pradeep Kumar SinghPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.
Elisa Nicoloso Simoes PiresPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.
Zu-Lin ChenPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.
Daniel TorrentePatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.
Marissa CalvanoPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.
Anurag SharmaElectron Microscopy Resource Center, The Rockefeller University, New York, NY, 10065.
Sidney StricklandPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.
Erin H NorrisPatricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, 10065.

Funding

Role of Fibrinogen in Alzheimer's DiseaseR01NS106668 · NINDS · ROCKEFELLER UNIVERSITY · PI Erin H. Norris, SIDNEY STRICKLAND · 2018 to 2026
$5.8M
NINDS NIH HHS R01 NS106668
6 · The paper itself

Abstract

Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer's disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of blood proteins like fibrinogen into the brain. Fibrinogen's interaction with the amyloid-beta (Aβ) peptide is known to worsen thrombotic and cerebrovascular pathways in AD. Lecanemab, an FDA-approved antibody therapy for AD, shows promising results in facilitating reduction of Aβ from the brain and slowing cognitive decline. Here we show that lecanemab blocks fibrinogen's binding to Aβ protofibrils, normalizing Aβ/fibrinogen-mediated delayed fibrinolysis and clot abnormalities

Indexed as

Alzheimer’s diseaseamyloid-betaARIABiological Sciences/NeurosciencefibrinogenfibrinolysislecanemabNAS section: Biochemistry

Identifiers

PMID38293058
PMCPMC10827200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.