ArticleFrontiers in neuroscience2023
Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Types of Neurons in the Myenteric Plexus of Human Gastric Corpus Identified by Multi-Layer Immunohistochemical Coding and Vagal Tracing.Neurogastroenterology and motility · 2026Article
- Multiscale analysis of the adult human superior hypogastric plexus and hypogastric nerve.Journal of anatomy · 2026Article
- Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026Review
- The Physiology of Enteric Glia.Annual review of physiology · 2025Review
- Extrinsic Innervation of Myenteric Plexus of Human Large Intestine Via Colonic Nerves.Cellular and molecular gastroenterology and hepatology · 2025Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Background and Aims: Viscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate sympathetic motility reflexes and may modulate glucose metabolism and feeding. We used rapid retrograde tracing from colonic nerves to identify VFNs in human colon for the first time, using Methods: Colonic nerves were identified in isolated preparations of human colon and set up for axonal tracing with biotinamide. After fixation, labeled VFN cell bodies were subjected to multiplexed immunohistochemistry for 12 established nerve cell body markers. Results: Biotinamide tracing filled 903 viscerofugal nerve cell bodies ( Conclusion: Viscerofugal neurons are present in human colon and show very diverse combinations of features. High proportions express ChAT, consistent with cholinergic synaptic outputs onto postganglionic sympathetic neurons in prevertebral ganglia.
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