Reversal of severe myopia by 24 years of hypotony with subsequent stable refraction after 2 years of normal intraocular pressure.

Purpose: To report sustained axial length shortening and hyperopic shift (refraction changed from -8 to -2 diopters) induced by 24 years of profound IOP (intraocular pressure) reduction with subsequent refractive stability 2 years after IOP rose to 11-17 mm Hg. Observations: A 25-year-old woman with elevated episcleral venous pressure glaucoma underwent non-penetrating trabeculectomy and subsequent laser goniopuncture in her left eye. She had chronically low IOP (1-12 mm Hg) for the next 24 years. Hypotony maculopathy was present in postoperative years 13-14 and 18-24 but resolved at age 49 when emesis-induced iris prolapse obstructed the filtering passage and transiently raised IOP to 40. Medical management and iridectomy with flap suturing stabilized IOP between 11 and 17 mm Hg.Refraction before OS trabeculectomy was OD -7.50/OS -9.00. In postoperative year 24 spherical equivalent phakic refraction was OD -9.00/OS -1.50. Biometry 1 year after resolution of hypotony showed axial lengths OD 24.8, OS 22.6 mm. Cataract surgery was performed in postoperative years 24/26 (OD/OS) with Tecnis DCBOO intraocular lenses of powers 14.0/21.5 diopters; postoperative refractions, 2 years after OS IOP rose to 11-17 mm Hg, were OD +0.25-0.50 x 015/OS -0.75-1.25 x 160 with 20/25 corrected acuity in each eye.Cardiovascular symptoms 24 years after the onset of her glaucoma led to a diagnosis of severe pulmonary hypertension. Conclusions and importance: This case demonstrates that 2 decades of chronic IOP reduction can reverse myopia (by > 2 mm reduction in axial length) with subsequent refractive stability 2 years after IOP normalization. In addition, the case shows that ocular signs of pulmonary hypertension may precede cardiovascular signs by 2 decades.