Evidence map›Paper›PMID 38292654›Full record

ArticleThe Lancet regional health. Western Pacific2024

Near-to-patient-testing to inform targeted antibiotic use for sexually transmitted infections in a public sexual health clinic: the NEPTUNE cohort study.

Lenka A Vodstrcil, Kay Htaik, Erica L Plummer, Vesna De Petra, Melodi G Sen, Deborah A Williamson, Jason J Ong, Jason Wu, Monica Owlad, Gerald Murray and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Western Pacific, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Lenka A VodstrcilCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Kay HtaikCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Erica L PlummerCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Vesna De PetraMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity at the University of Melbourne, Melbourne, Victoria, Australia.
Melodi G SenMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity at the University of Melbourne, Melbourne, Victoria, Australia.
Deborah A WilliamsonDepartment of Microbiology, Royal Melbourne Hospital, Melbourne, Australia.
Jason J OngCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Jason WuMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
Monica OwladMelbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
Gerald MurrayMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Eric P F ChowCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Christopher K FairleyCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Catriona S BradshawCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Melbourne Sexual Health Centre · AUThe University of Melbourne · AURoyal Women's Hospital · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Empiric treatment of sexually transmitted infections can cause unnecessary antibiotic use. We determined if near-to-patient-testing (NPT) for Methods: Clients attending with non-gonococcal urethritis (NGU), proctitis, as STI-contacts, or for an MG-test-of-cure (MG-TOC) between March and December 2021 were recruited. Participants received near-to-patient-testing (NPT-group) for the three STIs using the GeneXpert® System (Cepheid), and concurrent routine-testing by transcription-mediated-amplification (TMA; Aptima, Hologic). Antibiotic-use among NGU or proctitis cases in the NPT-group was compared to clinic-controls undergoing routine-testing only. The proportion in the NPT-group who notified partners <24 hrs of their STI-specific result was calculated. Findings: Among 904 consults by 808 NPT-participants, ≥1 STI was detected in 63/252 (25.0%) with NGU, 22/51 (43.1%) with proctitis, and 167/527 (31.7%) STI-contacts. MG was detected among 35/157 (22.3%) MG-TOC consults. Among NGU and proctitis cases, fewer in the NPT-group received empiric treatment compared to clinic-controls (29.4% [95% CI: 24.3-34.9%] Interpretation: Near-to-patient-testing significantly improved antibiotic use and a high proportion of individuals rapidly notified partners of STI-specific results, highlighting the broad benefits of timely diagnostic strategies for STIs in clinical decision making and partner notification. Funding: ARC ITRP Hub-grant; NHMRC.

Indexed as

Antimicrobial stewardshipChlamydia trachomatisEmpiric treatmentMycoplasma genitaliumNear to patient testingNeisseria gonorrhoeaePoint of care testingSexually transmitted infectionsSyndromic management

Identifiers

PMID38292654
PMCPMC10825687
OpenAlexW4390814544

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.