Evidence map›Paper›PMID 38292607›Full record

ArticleACS central science2024

Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue.

Adam G Kreutzer, Chelsea Marie T Parrocha, Sepehr Haerianardakani, Gretchen Guaglianone, Jennifer T Nguyen, Michelle N Diab, William Yong, Mari Perez-Rosendahl, Elizabeth Head, James S Nowick

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Adam G KreutzerDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0002-9724-6298
Chelsea Marie T ParrochaDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0002-6502-1297
Sepehr HaerianardakaniDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0003-1539-2345
Gretchen GuaglianoneDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0002-5189-2550
Jennifer T NguyenDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, California 92697, United States.
Michelle N DiabDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.
William YongDepartment of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California 92697, United States.
Mari Perez-RosendahlDepartment of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California 92697, United States.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California Irvine, Irvine, California 92697, United States.
James S NowickDepartment of Chemistry, University of California Irvine, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0002-2273-1029
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Antibodies Against Conformationally Defined Amyloid Oligomers in Alzheimer’s DiseaseRF1AG062296 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2018 to 2018
$3.0M
Structural and Biological Characterization of Diverse Oligomers Derived from AbetaRF1AG072587 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2021 to 2021
$1.4M
Structural and Biological Characterization of Diverse Oligomers Derived from AbetaR01AG072587 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NOWICK, JAMES S · 2024 to 2025
$994k
A Fast Pixel-Array Pilatus 2M Detector for Automated Macromolecular Crystallography Data CollectionS10OD026941 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, PAUL DAVID · 2019 to 2019
$563k
NCI NIH HHS P30 CA062203NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG072587NIA NIH HHS RF1 AG062296NIA NIH HHS RF1 AG072587NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P50 GM076516NIH HHS S10 OD026941
6 · The paper itself

Abstract

Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are important tools in Alzheimer's disease research and have emerged as promising Alzheimer's disease therapies. This paper reports the creation and characterization of a triangular Aβ trimer mimic composed of Aβ

Identifiers

PMID38292607
PMCPMC10823522
OpenAlexW4390046397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.