Evidence map›Paper›PMID 38292339›Full record

ArticleDisease markers2024

Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in Distinguishing Lung Cancer in People with HIV.

Joseph Baruch Baluku, Sharon Namiiro, Brenda Namanda, Martin Nabwana, Irene Andia-Biraro, William Worodria, Robert Salata, Sayoki Mfinanga, Stanton Gerson, Bruce Kirenga

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Joseph Baruch BalukuMakerere University Lung Institute, Kampala, Uganda.ORCID https://orcid.org/0000-0002-5852-9674
Sharon NamiiroDepartment of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Brenda NamandaDivision of Pulmonology, Kiruddu National Referral Hospital, Kampala, Uganda.
Martin NabwanaMakerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
Irene Andia-BiraroDepartment of Internal Medicine, Makerere University College of Health Sciences, Kampala, Uganda.ORCID https://orcid.org/0000-0002-8303-6046
William WorodriaMakerere University Lung Institute, Kampala, Uganda.ORCID https://orcid.org/0000-0002-8531-5567
Robert SalataDepartment of Medicine, UH Cleveland Medical Center, Cleveland, USA.
Sayoki MfinangaMuhimbili Center, National Institute for Medical Research, Dar es Salaam, Tanzania.ORCID https://orcid.org/0000-0001-9067-2684
Stanton GersonSchool of Medicine, Case Western Reserve University, Cleveland, USA.
Bruce KirengaMakerere University Lung Institute, Kampala, Uganda.ORCID https://orcid.org/0000-0002-2023-2840
Makerere University · UGCase Western Reserve University · USMUJHU Research Collaboration · UGNational Institute for Medical Research · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) demonstrate good diagnostic accuracy in distinguishing lung cancer patients from healthy individuals, primarily in HIV-negative populations. We determined the sensitivity (Se), specificity (Sp), and area under the curve (AUC) of the NLR and PLR in discriminating between people living with HIV (PLWH) with and without lung cancer. Methods: This is a comparative analysis of secondary data. Cases were PLWH with lung cancer from a retrospective cohort treated at the Uganda Cancer Institute. Controls were unmatched PLWH without lung cancer who were randomly selected from three HIV clinics in Uganda. Se, Sp, and AUC analysis and determination of optimal cutoffs were performed using receiver operating characteristic (ROC) curves. Results: Of 115 PLWH (18 cases and 97 controls), 83 (72.2%) were female, 110 (95.7) were on ART, and the median (IQR) age was 46 (38-51) years. The median (IQR) NLR was higher among cases than controls (3.53 (3.14-7.71) vs. 0.92 (0.67-1.09), Conclusion: The NLR and PLR discriminated PLWH with and without lung cancer and could be useful in PLWH with respiratory symptoms in whom lung cancer can easily be misdiagnosed as other lung pathology.

Indexed as

HIV InfectionsLung NeoplasmsBlood PlateletsFemaleHumansLymphocytesMaleMiddle AgedNeutrophilsPlatelet CountPrognosisRetrospective Studies

Identifiers

PMID38292339
PMCPMC10827363
OpenAlexW4391126598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.