Evidence map›Paper›PMID 38292332›Full record

ArticleClinical and translational radiation oncology2024

Multi-institutional experience of MR-guided stereotactic body radiation therapy for adrenal gland metastases.

Matthew Mills, Rupesh Kotecha, Roberto Herrera, Tugce Kutuk, Matthew Fahey, Evan Wuthrick, G Daniel Grass, Sarah Hoffe, Jessica Frakes, Michael D Chuong and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Matthew MillsDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States.
Rupesh KotechaDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States.
Roberto HerreraDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States.
Tugce KutukDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States.
Matthew FaheyUniversity of South Florida Morsani College of Medicine, Tampa, FL, United States.
Evan WuthrickDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States.
G Daniel GrassDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States.
Sarah HoffeDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States.
Jessica FrakesDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States.
Michael D ChuongDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States.
Stephen A RosenbergDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, FL, United States.
Moffitt Cancer Center · USBaptist Hospital of Miami · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: While dose escalation is associated with improved local control (LC) for adrenal gland metastases (AGMs), the proximity of gastrointestinal (GI) organs-at-risk (OARs) limits the dose that can be safely prescribed via CT-based stereotactic body radiation therapy (SBRT). The advantages of magnetic resonance-guided SBRT (MRgSBRT), including tumor tracking and online plan adaptation, facilitate safe dose escalation. Methods: This is a multi-institutional review of 57 consecutive patients who received MRgSBRT on a 0.35-T MR linac to 61 AGMs from 2019 to 2021. The Kaplan-Meier method was used to estimate overall survival (OS), progression-free survival (PFS), and LC, and the Cox proportional hazards model was utilized for univariate analysis (UVA). Results: Median follow up from MRgSBRT was 16.4 months (range [R]: 1.1-39 months). Median age was 67 years (R: 28-84 years). Primary histologies included non-small cell lung cancer (N = 38), renal cell carcinoma (N = 6), and melanoma (N = 5), amongst others. The median maximum diameter was 2.7 cm (R: 0.6-7.6 cm), and most AGMs were left-sided (N = 32). The median dose was 50 Gy (R: 30-60 Gy) in 5-10 fractions with a median BED Conclusions: We demonstrate that MRgSBRT achieves favorable early LC and no grade 3 + toxicity despite prescribing a median BED

Indexed as

Adrenal gland metastasisMR-guided radiation therapyOligometastasisStereotactic body radiation therapy

Identifiers

PMID38292332
PMCPMC10824679
OpenAlexW4390608751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.