Evidence map›Paper›PMID 38292249›Full record

ArticleBrain multiphysics2023

Neuroimaging, wearable sensors, and blood-based biomarkers reveal hyperacute changes in the brain after sub-concussive impacts.

Carissa Grijalva, Veronica A Mullins, Bryce R Michael, Dallin Hale, Lyndia Wu, Nima Toosizadeh, Floyd H Chilton, Kaveh Laksari

Open access · goldAbstract read
In one paragraph

Article in Brain multiphysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Carissa GrijalvaUniversity of Arizona, Department of Biomedical Engineering, Tucson, AZ, United States.
Veronica A MullinsUniversity of Arizona, School of Nutritional Sciences and Wellness, Tucson, AZ, United States.
Bryce R MichaelUniversity of Arizona, School of Nutritional Sciences and Wellness, Tucson, AZ, United States.
Dallin HaleUniversity of Arizona, Department of Physiology, Tucson, AZ, United States.
Lyndia WuUniverisity of British Columbia, Department of Mechanical Engineering, Vancouver, BC, Canada.
Nima ToosizadehUniversity of Arizona, Department of Biomedical Engineering, Tucson, AZ, United States.
Floyd H ChiltonUniversity of Arizona, School of Nutritional Sciences and Wellness, Tucson, AZ, United States.
Kaveh LaksariUniversity of Arizona, Department of Biomedical Engineering, Tucson, AZ, United States.
University of Arizona · USUniversity of British Columbia · CAUniversity of California, Riverside · US

Funding

Role of PUFA-Gene Interactions in Health DisparitiesR01AT008621 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FLOYD H CHILTON, Susan Schembre · 2016 to 2026
$5.4M
Enhanced Clinical Diagnosis through Imaging and Modeling: A Machine Learning Data Fusion FrameworkR21EB032187 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BABAEE, HESSAM, LAKSARI, KAVEH · 2021 to 2023
$636k
NCCIH NIH HHS R01 AT008621NIBIB NIH HHS R21 EB032187
6 · The paper itself

Abstract

Impacts in mixed martial arts (MMA) have been studied mainly in regard to the long-term effects of concussions. However, repetitive sub-concussive head impacts at the hyperacute phase (minutes after impact), are not understood. The head experiences rapid acceleration similar to a concussion, but without clinical symptoms. We utilize portable neuroimaging technology - transcranial Doppler (TCD) ultrasound and functional near infrared spectroscopy (fNIRS) - to estimate the extent of pre- and post-differences following contact and non-contact sparring sessions in nine MMA athletes. In addition, the extent of changes in neurofilament light (NfL) protein biomarker concentrations, and neurocognitive/balance parameters were determined following impacts. Athletes were instrumented with sensor-based mouth guards to record head kinematics. TCD and fNIRS results demonstrated significantly increased blood flow velocity (

Indexed as

Functional near-infrared spectroscopyHyperacuteSub-concussive impactsTranscranial Doppler ultrasound

Identifiers

PMID38292249
PMCPMC10827333
OpenAlexW4388980058

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.