Evidence map›Paper›PMID 38292194›Full record

ArticleGenes & diseases2024

ADAM8 inactivation retards intervertebral disc degeneration in mice.

Zuozhen Tian, Frances S Shofer, Mingyue Fan, Alec Z Sandroni, Lutian Yao, Lin Han, Ling Qin, Motomi Enomoto-Iwamoto, Yejia Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Zuozhen TianDepartment of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.
Frances S ShoferDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mingyue FanSchool of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Alec Z SandroniDepartment of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.
Lutian YaoDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lin HanSchool of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Ling QinDepartment of Orthopedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Motomi Enomoto-IwamotoDepartment of Orthopedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yejia ZhangDepartment of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.
University of Pennsylvania · USDrexel University · USFirst Hospital of China Medical University · CNUniversity of Maryland, Baltimore · USVeterans Health Administration · US

Funding

Inhibition of TNF-alpha Signaling to Reduce Intervertebral Disc InflammationR21AR078386 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2021 to 2022
$383k
ADAM8 in Intervertebral Disc DegenerationR21AR071623 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2018 to 2019
$364k
NIAMS NIH HHS R21 AR071623NIAMS NIH HHS R21 AR078386
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID38292194
PMCPMC10825293
OpenAlexW4385479033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.