Evidence map›Paper›PMID 38292047›Full record

ArticleFrontiers in aging neuroscience2023

Effects of STN-DBS on cognition and mood in young-onset Parkinson's disease: a two-year follow-up.

Jun Hong, Huimin Xie, Yuhua Chen, Di Liu, Tianyu Wang, Kun Xiong, Zhiqi Mao

Abstract read
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In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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  7. Article
  8. Early-Onset Parkinson's Disease: Unique Features and Management Approaches.Current neurology and neuroscience reports · 2025
    Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jun HongDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.
Huimin XieDepartment of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Yuhua ChenDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.
Di LiuDepartment of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Tianyu WangDepartment of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Kun XiongDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China.
Zhiqi MaoDepartment of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on the cognition and mood of patients with PD are still not uniformly concluded, and young-onset Parkinson's disease (YOPD) is even less explored. Objective: To observe the effectiveness of STN-DBS on the cognition and mood of YOPD patients. Methods: A total of 27 subjects, with a mean age at onset of 39.48 ± 6.24 and age at surgery for STN-DBS of 48.44 ± 4.85, were followed up preoperatively and for 2 years postoperatively. Using the Unified Parkinson disease rating scale (UPDRS), H&Y(Hoehn and Yahr stage), 39-Item Parkinson's Disease Questionnaire (PDQ-39), Mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) to assess motor, cognition, and mood. Results: At the 2-year follow-up after STN-DBS, YOPD patients showed significant improvements in motor and quality of life (UPDRS III: Conclusion: STN-DBS is a safe and effective treatment for YOPD. The mood improved significantly, and overall cognition was not impaired, were only verbal fluency decreased but did not affect the improvement in quality of life.

Indexed as

cognitiondeep brain stimulationmoodParkinson’s diseaseverbal fluency

Identifiers

PMID38292047
PMCPMC10824910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.