Evidence map›Paper›PMID 38291819›Full record

ArticleLasers in surgery and medicine2024

Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation.

Andrew Buzza, Kalista Tapas, Junqi Zhuo, Juanita J Anders, Stephen J Lewis, Michael W Jenkins, Michael Moffitt

Open access · hybridAbstract read
In one paragraph

Article in Lasers in surgery and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew BuzzaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-8601-4731
Kalista TapasDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Junqi ZhuoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Juanita J AndersDepartment of Anatomy, Physiology, and Genetics, Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Stephen J LewisDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA.
Michael W JenkinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Michael MoffittDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
Case Western Reserve University · USUniformed Services University of the Health Sciences · US

Funding

Integrated Neural Engineering and Rehabilitation Training ProgramT32EB004314 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI Jeffrey R Capadona, Robert F. Kirsch · 2004 to 2026
$6.1M
Characterization of the Properties and Mechanisms of Photobiomodulation-Induced Axonal Block and Evaluation as a Treatment for Neuropathic PainR01NS121372 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ANDERS, JUANITA J, JENKINS, MICHAEL W. · 2021 to 2025
$2.9M
NIBIB NIH HHS T32 EB004314NINDS NIH HHS R01 NS121372
6 · The paper itself

Abstract

objectivePhotobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored.

methodsIn a rodent chronic pain model (spared nerve injury-SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm

resultsAt emitter irradiances of 7.64 W/cm

conclusionsThe data from this study support the use of direct PBM on nerves of interest to reduce sensitivities associated with small-diameter fiber activity.

Indexed as

Chronic PainLow-Level Light TherapyNerve TissueHumansdirect PBMdosingenergy densityperipheral nerve painphotobiomodulationpower densityspared nerve injurysural nerve

Identifiers

PMID38291819
PMCPMC10954407
OpenAlexW4391392208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.