Evidence map›Paper›PMID 38291755›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2024

Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.

Débora Falcón, Eva M Calderón-Sánchez, Isabel Mayoral-González, Marta Martín-Bórnez, Alejandro Dominguez-Rodriguez, Encarnación Gutiérrez-Carretero, Antonio Ordóñez-Fernández, Juan Antonio Rosado, Tarik Smani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Débora FalcónGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain; Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Seville, 41009 Seville, Spain. Electronic address: dfalcon-ibis@us.es.
Eva M Calderón-SánchezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain; Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Seville, 41009 Seville, Spain.
Isabel Mayoral-GonzálezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain.
Marta Martín-BórnezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain; Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Seville, 41009 Seville, Spain.
Alejandro Dominguez-RodriguezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain.
Encarnación Gutiérrez-CarreteroGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain; Department of Surgery, Faculty of Medicine, University of Seville, 41009 Seville, Spain.
Antonio Ordóñez-FernándezGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain.
Juan Antonio RosadoDepartment of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.
Tarik SmaniGroup of Cardiovascular Pathophysiology, Institute of Biomedicine of Seville, University Hospital of Virgen del Rocio/University of Seville/CSIC, 41013 Seville, Spain; Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Seville, 41009 Seville, Spain. Electronic address: tasmani@us.es.
Instituto de Biomedicina de Sevilla · ESUniversidad de Extremadura · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The upregulation of Orai1 and subsequent store-operated Ca

Indexed as

Adenylyl CyclasesMyocardial InfarctionAnimalsCalciumCalcium SignalingCyclic AMPHumansORAI1 ProteinRatsUp-Regulationadenylyl cyclase 8Adenylyl CyclasesCalciumCyclic AMPORAI1 ProteinOrai1 protein, ratAdenylyl cyclase 8Ca(2+) handlingcardiac remodelingCREBOrai1

Identifiers

PMID38291755
PMCPMC10928147
OpenAlexW4391310741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.