Evidence map›Paper›PMID 38291622›Full record

ArticleEuropean stroke journal2024

The benefit of favorable venous outflow profile is mediated through reduced microvascular dysfunction in acute ischemic stroke.

Siyuan Li, Lan Hong, Wenhao Yang, Xinyu Liu, Yiran Zhang, Yifeng Ling, Zhijiao He, Xinru Wang, Yunhua Yue, Qiang Dong and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siyuan LiDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-5041-6499
Lan HongDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-4002-4627
Wenhao YangDepartment of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xinyu LiuDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-6566-3647
Yiran ZhangDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Yifeng LingDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Zhijiao HeDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Xinru WangDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Yunhua YueDepartment of Neurology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Qiang DongDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Feng WangDepartment of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xin ChengDepartment of Neurology, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
CHABLIS Collaboration

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionsVenous outflow (VO) is emerging as a marker of microvascular integrity in acute ischemic stroke. Using hemorrhagic transformation (HT) and infarct growth as mediators, we tested whether a favorable VO profile benefited functional outcome by reducing consequences of microvascular dysfunction. PATIENTS AND

methodsPatients receiving thrombectomy in three comprehensive stroke centers due to acute anterior circulation occlusion were included. VO was assessed semi-quantitatively by the opacification of ipsilateral vein of Labbé, Trolard and superficial middle cerebral vein. HT was graded on follow-up CT. Infarct growth volume (IGV) was the difference of final infarct volume and baseline core volume. The association of VO and functional independence (90-day modified Rankin Scale ⩽ 2) was examined by logistic regression. Mediation analysis was performed among VO, HT or IGV, and functional outcome in patients with or without recanalization, respectively.

resultsIn 242 patients analyzed, VO was strongly correlated with functional independence and VO ⩾ 4 was defined favorable. In 175 patients recanalized, favorable VO was associated with a reduced risk of HT (OR = 0.82, 95% CI 0.71-0.95, DISCUSSION AND

conclusionIn patients with acute anterior large vessel occlusion, the clinical benefit of VO may be mediated through reduced microvascular dysfunction.

Indexed as

Ischemic StrokeAgedAged, 80 and overBrain IschemiaCerebral VeinsFemaleHumansMaleMicrovesselsMiddle AgedThrombectomyTreatment OutcomeCerebral veinischemic strokemicrocirculationreperfusionthrombectomy

Identifiers

PMID38291622
PMCPMC11318418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.