Evidence map›Paper›PMID 38291290›Full record

ArticleNeuroscience bulletin2024

Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons.

Ru Gong, Linwei Qin, Linlin Chen, Ning Wang, Yifei Bao, Wei Lu

Abstract read
In one paragraph

Article in Neuroscience bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ru GongMinistry of Education (MOE) Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China.
Linwei QinMinistry of Education (MOE) Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China.
Linlin ChenDepartment of Neurobiology, Nanjing Medical University, Nanjing, 210096, China.
Ning WangDepartment of Neurobiology, Nanjing Medical University, Nanjing, 210096, China.
Yifei BaoMinistry of Education (MOE) Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China.
Wei LuMinistry of Education (MOE) Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, 210096, China. luwei@seu.edu.cn.ORCID http://orcid.org/0000-0001-5920-564X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular mechanism underlying the surface transport of NMDARs is largely unknown. Here we identified myosin Va (MyoVa) as the specific motor protein that traffics NMDARs in hippocampal neurons. We found that MyoVa associates with NMDARs through its cargo binding domain. This association was increased during NMDAR surface transport. Knockdown of MyoVa suppressed NMDAR transport. We further demonstrated that Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2HippocampusMyosin Type VNeuronsReceptors, N-Methyl-D-AspartateAnimalsCells, CulturedHumansMyosin Heavy ChainsProtein TransportRatsRats, Sprague-DawleyCalcium-Calmodulin-Dependent Protein Kinase Type 2Myo5a protein, ratMyosin Heavy ChainsMyosin Type VReceptors, N-Methyl-D-AspartateCaMKIIMemoryMyosin VaNMDA receptorTransport

Identifiers

PMID38291290
PMCPMC11306496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.