ArticleNature neuroscience2024
Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen.
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Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
19.6field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 60 citations in OpenAlex.
- Upregulation of reward mesolimbic activity and immune response to vaccination: a randomized controlled trial.Nature medicine · 2026Trial
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- An mPFC-DMV cortical-autonomic-immune axis governs stress-induced immune dysregulation in sepsis.Molecular psychiatry · 2026Article
- Cancer-related pain: A bidirectional modulator of cancer progression.Clinical and translational medicine · 2026Review
- Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance.The journal of headache and pain · 2026Article
- Lipopolysaccharide hydrolysis-targeting nano-chimeras detoxify endotoxin through specific adsorption and efficient degradation.Nature communications · 2026Article
- Applications of micro/nano drug delivery systems in cancer pain management.Bioactive materials · 2026Review
- PVNJournal of neuroinflammation · 2026Article
- Hcn1-dependent engram neurons in the PVN encode gastric inflammatory sensitization.Science advances · 2026Article
- Cross-Organ Neuroimmunology of Behavior.Annual review of immunology · 2026Review
- Macrophage-derived extracellular vesicles promote T cell-dependent inflammatory pain resolution.bioRxiv : the preprint server for biology · 2026Article
- Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- A paraventricular hypothalamic control of social stress susceptibility by targeting brown adipose tissue β3 adrenoceptor.Communications biology · 2026Article
- Clinical Practice and Mechanism Exploration on Traditional Chinese Spinal Manipulative Therapy for Spinal Degenerative Diseases: A Review.Chinese journal of integrative medicine · 2026Review
- A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice.Nature communications · 2026Article
- Article
- Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes.Diabetes · 2026Review
- Distinct and Shared Brain-Wide Activation Patterns in Mouse Models of Inflammatory and Neuropathic Pain.Journal of pain research · 2026Article
- [Research progress on vagus nerve stimulation in the treatment of chronic pain].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- A brain-to-small intestine circuit mediates morphine-induced constipation in male mice.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Xia Zhu *Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.ORCID http://orcid.org/0000-0001-6732-9570
Ji-Ye Huang *Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Wan-Ying Dong *Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Hao-Di Tang *Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Si XuDepartment of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, P. R. China.
Qielan WuDepartment of Oncology, The First Affiliated Hospital of USTC, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Huimin ZhangDepartment of Oncology, The First Affiliated Hospital of USTC, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Ping-Kai ChengDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Yuxin JinDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Meng-Yu ZhuCollege & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, P. R. China.
Wan ZhaoDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technique of China, Hefei, P. R. China.ORCID http://orcid.org/0000-0001-9510-6374
Yu MaoDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.
Haitao WangSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, P. R. China.
Yan ZhangDepartment of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China.ORCID http://orcid.org/0000-0001-9405-1180
Hao WangInstitute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, P. R. China.ORCID http://orcid.org/0000-0001-7958-3090
Wenjuan Tao *College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, P. R. China. wjtao01@ahmu.edu.cn.ORCID http://orcid.org/0000-0002-0525-0514
Yanghua Tian *Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, P. R. China. ayfytyh@126.com.ORCID http://orcid.org/0000-0001-5038-0599
Li Bai *Department of Oncology, The First Affiliated Hospital of USTC, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China. baili@ustc.edu.cn.ORCID http://orcid.org/0000-0002-9028-1920
Zhi Zhang *Department of Anesthesiology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P. R. China. zhizhang@ustc.edu.cn.ORCID http://orcid.org/0000-0002-4205-3181
University of Science and Technology of China · CNAnhui Medical University · CNAnhui University of Traditional Chinese Medicine · CN
Funding
China Postdoctoral Science Foundation 2020M682018National Natural Science Foundation of China (National Science Foundation of China) 32025017National Natural Science Foundation of China (National Science Foundation of China) 32100808National Natural Science Foundation of China (National Science Foundation of China) 32121002National Natural Science Foundation of China (National Science Foundation of China) 32241013
Abstract
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (T
Indexed as
Central Amygdaloid NucleusNeuralgiaAnimalsGABAergic Neuronsgamma-Aminobutyric AcidMaleMiceSomatosensory CortexSpleenVagus Nervegamma-Aminobutyric Acid
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.