ArticleScientific reports2024
Right heart and left atrial strain to differentiate cardiac amyloidosis and Fabry disease.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Fabry disease cardiomyopathy: A state-of-the-art review.Progress in cardiovascular diseasesPooled it
- Article
- Applications of Left Atrial Strain in Cardiovascular Disease: A Comprehensive Review of Recent Evidence.Reviews in cardiovascular medicine · 2026Review
- Triplane Left Atrial Reservoir Strain in Cardiac Amyloidosis: A Comparative Study with Rhythm-Matched Controls.Clinics and practice · 2026Article
- Echocardiographic Deformation Imaging of the Right Atrium: A New Paradigm in Noninvasive Hemodynamic Assessment.Current cardiology reports · 2026Review
- The left ventricular mechanical dispersion as a marker of disease severity in transthyretin cardiac amyloidosis.Scientific reports · 2025Observational
- Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Right atrial strain in Anderson-Fabry disease.Frontiers in cardiovascular medicine · 2025Article
- Myocardial Mechanics and Valvular and Vascular Abnormalities in Cardiac Amyloidosis.Journal of clinical medicine · 2024Review
- Role of standard echocardiography in Anderson-Fabry disease.Frontiers in cardiovascular medicine · 2024Review
- Cardiac involvement in Anderson-Fabry disease. The role of advanced echocardiography.Frontiers in cardiovascular medicine · 2024Review
- Clinical Relevance of Right Atrial Strain Using Speckle-tracking Echocardiography: Emerging Insights and Future Prospective.Journal of cardiovascular echographyReview
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Echocardiographic differentiation of cardiac amyloidosis (CA) and Fabry disease (FD) is often challenging using standard echocardiographic parameters. We retrospectively analyzed the diagnostic accuracy of right heart and left atrial strain parameters to discriminate CA from FD using receiver operating characteristic curve analyses and logistic regression models. A total of 47 FD and 88 CA patients with left ventricular wall thickening were analyzed. The comparison of both cardiomyopathies revealed significantly reduced global and free wall longitudinal right ventricular strain (RVS; global RVS: CA - 13 ± 4%, n = 67, vs. FD - 18 ± 4%, n = 39, p < 0.001) as well as right atrial strain (RAS; reservoir RAS: CA 12 ± 8%, n = 70, vs. FD 26 ± 9%, n = 40, p < 0.001) and left atrial strain (LAS) in CA patients. Individually, global RVS as well as phasic LAS and RAS showed the highest diagnostic accuracy to distinguish CA and FD. The best diagnostic accuracy was achieved by combining the age, basal RV diameter, global RVS, and reservoir and conduit RAS (area under the curve 0.96 [95% CI 0.90-1.00]). Differential echocardiographic diagnostic work-up of patients with suspected CA or FD can be improved by integrating structural and functional parameters of the right heart and the left atrium.Trial registration: DRKS00027403.
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