Evidence map›Paper›PMID 38291187›Full record

ArticleEJNMMI physics2024

Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography.

Sara de Scals, Luis Mario Fraile, José Manuel Udías, Laura Martínez Cortés, Marta Oteo, Miguel Ángel Morcillo, José Luis Carreras-Delgado, María Nieves Cabrera-Martín, Samuel España

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in EJNMMI physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sara de ScalsGrupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de Madrid, Madrid, Spain.
Luis Mario FraileGrupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de Madrid, Madrid, Spain.
José Manuel UdíasGrupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de Madrid, Madrid, Spain.
Laura Martínez CortésUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Marta OteoUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Miguel Ángel MorcilloUnidad de Aplicaciones Médicas de las Radiaciones Ionizantes, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
José Luis Carreras-DelgadoInstituto de Investigación del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
María Nieves Cabrera-MartínInstituto de Investigación del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
Samuel EspañaGrupo de Física Nuclear, EMFTEL and IPARCOS, Universidad Complutense de Madrid, Madrid, Spain. sespana@ucm.es.ORCID http://orcid.org/0000-0001-9092-4597
Universidad Complutense de Madrid · ESCentro de Investigaciones Energéticas, Medioambientales y Tecnológicas · ESInstituto de Investigación Sanitaria del Hospital Clínico San Carlos · ES

Funding

Ministerio de Ciencia e Innovación RYC2018-024495-IMinisterio de Ciencia e Innovación TED2021-129933B-C21Universidad Complutense de Madrid PR27/21-009
6 · The paper itself

Abstract

Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood plasma. Traditionally, obtaining the AIF requires invasive procedures, such as arterial catheterization, which can be challenging, time-consuming, and associated with potential risks. Therefore, the development of non-invasive techniques for AIF measurement is highly desirable. This study presents a detector for the non-invasive measurement of the AIF in PET studies. The detector is based on the combination of scintillation fibers and silicon photomultipliers (SiPMs) which leads to a very compact and rugged device. The feasibility of the detector was assessed through Monte Carlo simulations conducted on mouse tail and human wrist anatomies studying relevant parameters such as energy spectrum, detector efficiency and minimum detectable activity (MDA). The simulations involved the use of

Indexed as

Arterial input functionPharmacokinetic studiesPositron emission tomographyScintillation fibers

Identifiers

PMID38291187
PMCPMC10828322
OpenAlexW4391399636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.