Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024
Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- A dense-sampling investigation of interoceptive variation across the menstrual cycle: the Cyclic Hormones and Interoception with Repeated Profiling (CHIRP) Study.Brain, behavior, & immunity - health · 2026Article
- Heartbeat-evoked potentials reveal interoceptive dysfunction in clinical disorders: Experimental frameworks and promising applications.Psychological medicine · 2026Review
- The effects of exercise on generalized anxiety symptoms in adults: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Associations between self-reported interoception and resting-state EEG markers in panic disorder: heartbeat-evoked potentials and spectral power.BMC psychology · 2026Article
- Exploring the role of interoception in anxious traits and symptoms.Frontiers in psychiatry · 2026Article
- Interpreting Anxiety Disorders From the Perspective of Interoceptive Computational Models.Brain and behavior · 2025Review
- Neural Sensitivity to the Heartbeat Is Modulated by Fluctuations in Affective Arousal during Spontaneous Thought.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Altered Gastrointestinal Interoception in Anorexia Nervosa Predicts Relapse.medRxiv : the preprint server for health sciences · 2025Article
- Neural sensitivity to the heartbeat is modulated by fluctuations in affective arousal during spontaneous thought.bioRxiv : the preprint server for biology · 2025Article
- Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Manipulation of interoceptive signaling biases decision making in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- Computational Approaches for Uncovering Interoceptive Mechanisms in Psychiatric Disorders and Their Biological Basis.Current topics in behavioral neurosciences · 2025Review
- Interoceptive Signals Bias Decision Making in Rhesus Macaques.bioRxiv : the preprint server for biology · 2024Article
- Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: A proof-of-concept study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication and extension of previous results.Biological psychology · 2024Article
- Article
- Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study.bioRxiv : the preprint server for biology · 2024Article
- Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication study.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
- Update of
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Hyperarousal symptoms in generalized anxiety disorder (GAD) are often incongruent with the observed physiological state, suggesting that abnormal processing of interoceptive signals is a characteristic feature of the disorder. To examine the neural mechanisms underlying interoceptive dysfunction in GAD, we evaluated whether adrenergic modulation of cardiovascular signaling differentially affects the heartbeat-evoked potential (HEP), an electrophysiological marker of cardiac interoception, during concurrent electroencephalogram and functional magnetic resonance imaging (EEG-fMRI) scanning. Intravenous infusions of the peripheral adrenergic agonist isoproterenol (0.5 and 2.0 micrograms, μg) were administered in a randomized, double-blinded and placebo-controlled fashion to dynamically perturb the cardiovascular system while recording the associated EEG-fMRI responses. During the 0.5 μg isoproterenol infusion, the GAD group (n = 24) exhibited significantly larger changes in HEP amplitude in an opposite direction than the healthy comparison (HC) group (n = 24). In addition, the GAD group showed significantly larger absolute HEP amplitudes than the HC group during saline infusions, when cardiovascular tone did not increase. No significant group differences in HEP amplitude were identified during the 2.0 μg isoproterenol infusion. Using analyzable blood oxygenation level-dependent fMRI data from participants with concurrent EEG-fMRI data (21 GAD and 21 HC), we found that the aforementioned HEP effects were uncorrelated with fMRI signals in the insula, ventromedial prefrontal cortex, dorsal anterior cingulate cortex, amygdala, and somatosensory cortex, brain regions implicated in cardiac signal processing in prior fMRI studies. These findings provide additional evidence of dysfunctional cardiac interoception in GAD and identify neural processes at the electrophysiological level that may be independent from blood oxygen level-dependent responses during peripheral adrenergic stimulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.