SynthesisNature communications2024
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 8 pooled it
25.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 8 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis.Nature genetics · 2026Pooled it
- Genetic drivers of etiologic heterogeneity in thyroid cancer.Nature communications · 2026Pooled it
- Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.Nature genetics · 2026Pooled it
- Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.Nature genetics · 2026Pooled it
- Genome-wide association study and polygenic risk prediction of hypothyroidism.Nature genetics · 2025Pooled it
- The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension.Mayo Clinic proceedings · 2025Pooled it
- Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.Nature communications · 2025Pooled it
- Causal validation of the relationship between 35 blood and urine biomarkers and hyperthyroidism: a bidirectional Mendelian randomization study and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- The Interplay Between Thyroid Cancer and Cardiovascular Disease: Shared Mechanisms, Treatment Implications, and Survivorship Perspectives.Cardiovascular toxicology · 2026Review
- Thyroid dysfunction and cardiovascular disease.European heart journal · 2026Review
- Maternal thyroid hormone trajectories and cognitive develpoment in preschoolers: the Ma'anshan Birth Cohort.Pediatric research · 2026Article
- Exploring socio-economic, biochemical, and genetic factors influencing thyroid status in Indian school-going adolescents.Journal of human genetics · 2026Article
- TSH reference intervals among Sub-Saharan African adults: a pilot study in Cameroon.BMC endocrine disorders · 2026Article
- Widespread genetic effect heterogeneity impacts bias and power in nonlinear Mendelian randomization.medRxiv : the preprint server for health sciences · 2026Article
- Establishment of Reference Intervals for Plasma TSH Across the Lifespan in an Algerian Mediterranean Population.Journal of clinical laboratory analysis · 2026Article
- Association between cardiometabolic index and thyroid function: insights from NHANES.Hormones (Athens, Greece) · 2026Article
- Circulating sex steroids do not influence risk of thyroid malignancy: insights from a bidirectional Mendelian randomization.Gland surgery · 2026Article
- The associations between resting and total energy expenditure, physical activity, and thyroid hormone levels in adult females.Frontiers in physiology · 2026Article
- Thyroid function and risk of sepsis: a population-based prospective cohort study with traditional and genetic epidemiological analyses.Frontiers in endocrinology · 2026Article
- Genetically Predicted Gastroesophageal Reflux Disease and Common Thyroid Disorders: A Two-sample Mendelian Randomization Study.Current medicinal chemistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
143 authors at 20 institutions in 16 countries.
Rosalie B T M Sterenborg *Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4758-9185
Inga Steinbrenner *Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0003-0851-5773
Yong Li *Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2651-8791
Melissa N Bujnis *The University of Utah, Salt Lake City, UT, USA.
Tatsuhiko Naito *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-2779-4600
Eirini Marouli *William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.ORCID 0000-0001-6179-1609
Tessel E GaleslootDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Oladapo BabajideWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Laura AndreasenLaboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Arne AstrupDepartment of Obesity and Nutritional Sciences, The Novo Nordisk Foundation, Hellerup, Denmark.ORCID 0000-0001-8968-8996
Bjørn Olav ÅsvoldK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-3837-2101
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Toscana Centro, Florence, Italy.
Marian BeekmanDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-0585-6206
John P BeilbySchool of Biomedical Sciences, The University of Western Australia, Perth, WA, 6009, Australia.ORCID 0000-0002-4915-2254
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thibaud BoutinMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8509-148X
Suzanne J BrownDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.ORCID 0000-0002-8413-561X
Ben BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0002-3058-1059
Purdey J CampbellDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Anne R CappolaDivision of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania, Philadelphia, PA, USA.
Graziano CeresiniOncological Endocrinology, University of Parma, Parma, Italy.
Layal ChakerDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.ORCID 0000-0003-3357-0862
Maria Pina ConcasInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0003-3598-2537
Rodrigo Coutinho de AlmeidaDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Simone M CrossQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy.
Ian J DearyLothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.ORCID 0000-0002-1733-263X
Alisa Devedzic KjaergaardSteno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Blvd. 11, Entrance A, 8200, Aarhus, Denmark.ORCID 0000-0003-3899-1324
Justin B Echouffo TcheuguiDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Christina EllervikHarvard Medical School, Boston, USA.ORCID 0000-0002-3088-4375
Johan G ErikssonDepartment of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland.
Luigi FerrucciLongitudinal Study Section, National Institute on Aging, Baltimore, MD, USA.ORCID 0000-0002-6273-1613
Jan FreudenbergRegeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
GHS DiscovEHR
Regeneron Genetics Center
Christian FuchsbergerInstitute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy.
Christian GiegerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-6986-9554
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.
Martin GögeleInstitute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy.
Sarah E GrahamDepartment of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-1271-2489
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Ivana GunjačaDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia.ORCID 0000-0002-7056-6443
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Barbara N HardingCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.ORCID 0000-0002-4941-5106
Stig HaunsøLaboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Jennie HuiPathwest Laboratory Medicine WA, Nedlands, WA, 6009, Australia.
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-3246-8359
Eero KajantieFinnish Institute for Health and Welfare, Population Health Unit, Helsinki and Oulu, Oulu, Finland.ORCID 0000-0001-7081-8391
Jørgen K KantersDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3267-4910
Line L KårhusCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Lambertus A L M KiemeneyDepartment for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-2368-1326
Margreet KloppenburgDepartments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Brigitte KühnelResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4310-5297
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Bruno LapauwDepartment of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
Graham LeeseNHS Tayside, Scotland, Dundee, UK.ORCID 0000-0003-0570-5678
Shuo LiDepartment of Biostatistics, Boston University, Boston, MA, USA.ORCID 0000-0003-2331-2448
David C M LiewaldLothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.ORCID 0000-0002-0544-7368
Allan LinnebergCenter of Physiological Research, University of California San Francisco, San Francisco, USA.ORCID 0000-0002-0994-0184
Jesus V T LomincharNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID 0000-0003-3137-6337
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID 0000-0003-4069-8020
Antonela MatanaDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia.
Marcel E MeimaAcademic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Thomas MeitingerInstitute for Human Genetics, Technical University of Munich, Munich, Germany.ORCID 0000-0002-8838-8403
Ingrid MeulenbeltDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-7786-7081
Braxton D MitchellUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, USA.ORCID 0000-0003-4920-4744
Line T MøllehaveCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Samia MoraDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.ORCID 0000-0001-6283-0980
Silvia NaitzaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy.
Matthias NauckDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID 0000-0002-6678-7964
Romana T Netea-MaierDepartment of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-9603-0460
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-7801-809X
Casia NursyifaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-0311-8472
Stefano OnanoIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy.ORCID 0000-0002-8478-5137
Areti PapadopoulouWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.ORCID 0000-0003-3158-7951
Colin N A PalmerDivision of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK.ORCID 0000-0002-6415-6560
Cristian PattaroInstitute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3321-3972
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0001-6645-0985
Maik PietznerMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID 0000-0003-3437-9963
Ozren PolašekDepartment of Public Health, University of Split, School of Medicine, Split, Croatia.
Peter P PramstallerInstitute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Ante PundaDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Debashree RayDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.ORCID 0000-0002-0979-2935
Paul RedmondLothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.
J Brent RichardsLady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada.ORCID 0000-0002-3746-9086
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.
Tom C RussLothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.ORCID 0000-0001-9797-2188
Kathleen A RyanUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, USA.ORCID 0000-0003-1158-8455
Morten Salling OlesenLaboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-9477-5322
Ulla T SchultheissInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-7541-5310
Elizabeth SelvinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.ORCID 0000-0002-3539-2070
Moneeza K SiddiquiWolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID 0000-0001-9055-3896
Carlo SidoreIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy.ORCID 0000-0001-7504-7477
P Eline SlagboomDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-2875-4723
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4821-430X
Enrique Soto-PedreDivision of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK.
Tim D SpectorThe Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, SE1 7EH, UK.ORCID 0000-0002-9795-0365
Beatrice SpedicatiInstitute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.ORCID 0000-0002-7432-4708
Sundararajan SrinivasanDivision of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK.
John M StarrAlzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom.
David J StottInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Toshiko TanakaLongitudinal Study Section, National Institute on Aging, Baltimore, MD, USA.
Vesela TorlakDepartment of Nuclear Medicine, University Hospital Split, Split, Croatia.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0001-5006-0528
Johanna TuhkanenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
André G UitterlindenDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-7276-3387
Erik B van den AkkerDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-7693-0728
Tibbert van den EyndePrecision Healthcare University Research Institute, Queen Mary University of London, London, UK.
Melanie M van der KlauwDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-7178-009X
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Charlotte VerrokenDepartment of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium.
W Edward VisserAcademic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-5248-863X
Dina VojinovicDepartment of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.
Melanie WaldenbergerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-0583-5093
John P WalshDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.ORCID 0000-0003-1422-2993
Stefan WeissDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID 0000-0002-3553-4315
Cristen J WillerDepartment of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-5645-4966
Scott G WilsonSchool of Biomedical Sciences, The University of Western Australia, Perth, WA, 6009, Australia.ORCID 0000-0002-0357-1373
Bruce H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-9262-6921
Hanneke J C M WoutersDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-7133-4970
Qiong YangDepartment of Biostatistics, Boston University, Boston, MA, USA.ORCID 0000-0002-3658-1375
Tatijana ZemunikDepartment of Medical Biology, University of Split, School of Medicine, Split, Croatia.ORCID 0000-0001-8120-2891
Wei ZhouAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-7719-0859
Gu ZhuQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Sebastian ZöllnerDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-7362-156X
Johannes W A SmitDepartment of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.
Robin P PeetersAcademic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Anna KöttgenInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-4671-3714
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany. ateumer@uni-greifswald.de.ORCID 0000-0002-8309-094X
Marco MediciDepartment of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands. m.medici@erasmusmc.nl.
University of Copenhagen · DKLeiden University Medical Center · NLRadboud University Nijmegen · NLQueen Mary University of London · GBBrigham and Women's Hospital · USEurac Research · ITNHS Lothian · GBThe University of Western Australia · AUJohns Hopkins University · USUniversity Medical Center Groningen · NLUniversity of Helsinki · FIBoston University · USQIMR Berghofer Medical Research Institute · AUNational Institute on Aging · USNorwegian University of Science and Technology · NOUniversity of Freiburg · DEUniversity of Maryland, Baltimore · USBroad Institute · USErasmus MC · NLInstitute of Genetic and Biomedical Research · IT
Funding
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MHuman Genetic Variation and DiseaseR35GM118335 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JORDE, LYNN · 2016 to 2025
$5.1MUniversity of Utah Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism ResearchT32DK110966 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck, Marcus Guy Pezzolesi · 2016 to 2026
$2.6MMidcareer Investigator Award in Patient-Oriented Research in AgingK24AG042765 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2013 to 2024
$1.7MSubclinical thyroid dysfunction in the elderlyR01AG032317 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2009 to 2013
$1.4MBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council MC_UU_00007/10NHLBI NIH HHS R01 HL105756NIA NIH HHS K24 AG042765NIA NIH HHS R01 AG032317NIDDK NIH HHS T32 DK110966NIGMS NIH HHS R35 GM118335
Abstract
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases.
Indexed as
Thyroid GlandThyroxineGenome-Wide Association StudyHumansThyrotropinTriiodothyronineThyrotropinThyroxineTriiodothyronine
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