Evidence map›Paper›PMID 38290738›Full record

ArticleAJNR. American journal of neuroradiology2024

Automated Assessment of the DWI-FLAIR Mismatch in Patients with Acute Ischemic Stroke: Added Value to Routine Clinical Practice.

E Tavakkol, S Kihira, M McArthur, J Polson, H Zhang, C W Arnold, B Yoo, M Linetsky, B Salehi, L Ledbetter and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

E TavakkolFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-2869-8087
S KihiraFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-1001-8741
M McArthurFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0009-0001-0037-1878
J PolsonFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-0518-4841
H ZhangFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-9412-7584
C W ArnoldFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-4119-8143
B YooFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-6877-4756
M LinetskyFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.
B SalehiFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.
L LedbetterFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-4531-4671
C KimFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.
R JahanFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-7389-6352
G DuckwilerFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-5459-396X
J L SaverDepartment of Neurology (J.L.S., D.S.L.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-9141-2251
D S LiebeskindDepartment of Neurology (J.L.S., D.S.L.), University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-5109-8736
K NaelFrom the Department of Radiological Sciences (E.T., S.K., M.M. J.P., H.Z., C.W.A., B.Y., M.L., B.S., L.L., C.K., R.J., G.D., K.N.), University of California, Los Angeles, Los Angeles, California kambiznael@gmail.com.ORCID 0000-0002-4194-9488
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe DWI-FLAIR mismatch is used to determine thrombolytic eligibility in patients with acute ischemic stroke when the time since stroke onset is unknown. Commercial software packages have been developed for automated DWI-FLAIR classification. We aimed to use e-Stroke software for automated classification of the DWI-FLAIR mismatch in a cohort of patients with acute ischemic stroke and in a comparative analysis with 2 expert neuroradiologists. MATERIALS AND

methodsIn this retrospective study, patients with acute ischemic stroke who had MR imaging and known time since stroke onset were included. The DWI-FLAIR mismatch was evaluated by 2 neuroradiologists blinded to the time since stroke onset and automatically by the e-Stroke software. After 4 weeks, the neuroradiologists re-evaluated the MR images, this time equipped with automated predicted e-Stroke results as a computer-assisted tool. Diagnostic performances of e-Stroke software and the neuroradiologists were evaluated for prediction of DWI-FLAIR mismatch status.

resultsA total of 157 patients met the inclusion criteria. A total of 82 patients (52%) had a time since stroke onset of ≤4.5 hours. By means of consensus reads, 81 patients (51.5%) had a DWI-FLAIR mismatch. The diagnostic accuracy (area under the curve/sensitivity/specificity) of e-Stroke software for the determination of the DWI-FLAIR mismatch was 0.72/90.0/53.9. The diagnostic accuracy (area under the curve/sensitivity/specificity) for neuroradiologists 1 and 2 was 0.76/69.1/84.2 and 0.82/91.4/73.7, respectively; both significantly (

conclusionsThis automated quantitative approach for DWI-FLAIR mismatch provides results comparable with those of human experts and can improve the diagnostic accuracies of expert neuroradiologists in the determination of DWI-FLAIR status.

Indexed as

Diffusion Magnetic Resonance ImagingIschemic StrokeAgedAged, 80 and overFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedReproducibility of ResultsRetrospective StudiesSensitivity and SpecificitySoftware

Identifiers

PMID38290738
PMCPMC11288547
OpenAlexW4391360757

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.