ArticleNeuron2024
Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
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Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
21.5field-weighted citation impact, top 1% of its field
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- mTORC2-NaChannels (Austin, Tex.) · 2026Article
- Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids.Neuron · 2026Article
- Genetic Rescue of Disrupted Synaptic Protein Interaction Network Dynamics Following SYNGAP1 Reactivation.Molecular & cellular proteomics : MCP · 2026Article
- Subcortical Dendritic Scaffolding in Autism Spectrum Disorder: A Testable ANK2-SCN2A-SHANK Framework.International journal of molecular sciences · 2026Review
- In situ proteomics unveils specialized domains for extrasynaptic signaling on neuronal cilia.Science advances · 2026Article
- Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model ofbioRxiv : the preprint server for biology · 2026Article
- Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder.Genome biology · 2026Article
- Reframing the axon initial segment: Giant ankyrin-G as a modulator of excitability and plasticity in neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Neurologist's Black Swan: Molecular Basis of Prenatal Seizures.International journal of molecular sciences · 2025Review
- MeCP2 regulates telencephalic development in human cerebral organoids.Cell reports · 2025Article
- Degraded sensory coding in a mouse model ofbioRxiv : the preprint server for biology · 2025Article
- Genetic rescue of disrupted synaptic protein interaction network dynamics followingbioRxiv : the preprint server for biology · 2025Article
- Autism-associatedProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus.bioRxiv : the preprint server for biology · 2025Article
- Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism.Journal of visualized experiments : JoVE · 2025Article
- Autism-related proteins form a complex to maintain the striatal asymmetry in mice.Cell research · 2025Article
- Cytoskeletal scaffolding of NaCurrent opinion in cell biology · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Andrew D NelsonWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Amanda M CatalfioDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
Julie P GuptaDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
Lia MinDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
René N Caballero-FloránDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kendall P DeanCellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI, USA.
Carina C ElviraCellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI, USA.
Kimberly D DerderianWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Henry KyoungWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Atehsa SahagunWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Stephan J SandersWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Kevin J BenderWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: kevin.bender@ucsf.edu.
Paul M JenkinsDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: pjenkins@umich.edu.
University of Michigan–Ann Arbor · USUniversity of California, San Francisco · US
Funding
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MCellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1MConvergent mechanisms for neurodevelopmental disorder genesR01MH126960 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nadav Ahituv, Kevin J Bender · 2021 to 2026
$3.5MCRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorderR01MH136475 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kevin J Bender, Daniel Feldman · 2024 to 2026
$2.0MThe function of SCN2A in neocortexR01MH125978 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENDER, KEVIN J · 2021 to 2025
$2.0MCTSA Postdoctoral T32 at the University of MichiganT32TR004764 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, Steven Edward Harte · 2024 to 2026
$1.4MConvergent cellular and network mechanisms of ASD risk genesK99MH135209 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, ANDREW D · 2024 to 2025
$234kCellular Mechanisms of Convergence Among Autism Spectrum Disorder GenesF32MH125536 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, ANDREW D · 2021 to 2023
$153kNCATS NIH HHS T32 TR004764NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM145470NIMH NIH HHS F32 MH125536NIMH NIH HHS K99 MH135209NIMH NIH HHS R01 MH125978NIMH NIH HHS R01 MH126960NIMH NIH HHS R01 MH136475
Abstract
Dysfunction in sodium channels and their ankyrin scaffolding partners have both been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In particular, the genes SCN2A, which encodes the sodium channel Na
Indexed as
Autism Spectrum DisorderAutistic DisorderNeocortexAnimalsAnkyrinsDendritesMiceNAV1.2 Voltage-Gated Sodium ChannelPyramidal CellsAnk2 protein, mouseAnkyrinsNAV1.2 Voltage-Gated Sodium ChannelScn2a protein, mouseankyrinautism spectrum disorderaxon initial segmentconvergencedendriteexcitabilitylocalizationmedial prefrontal cortexsodium channelsynapse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.