Evidence map›Paper›PMID 38289965›Full record

ArticlePLOS digital health2024

Artificial intelligence in fracture detection with different image modalities and data types: A systematic review and meta-analysis.

Jongyun Jung, Jingyuan Dai, Bowen Liu, Qing Wu

Open access · goldAbstract read
In one paragraph

Article in PLOS digital health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  13. Clinical implementation of AI for vertebral fracture detection in CT aligned with fracture liaison services: high prevalence of undiagnosed vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jongyun JungDepartment of Biomedical Informatics (Dr. Qing Wu, Jongyun Jung, and Jingyuan Dai), College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.ORCID https://orcid.org/0000-0002-9258-5397
Jingyuan DaiDepartment of Biomedical Informatics (Dr. Qing Wu, Jongyun Jung, and Jingyuan Dai), College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.ORCID https://orcid.org/0000-0001-5096-0112
Bowen LiuDepartment of Mathematics and Statistics, Division of Computing, Analytics, and Mathematics, School of Science and Engineering (Bowen Liu), University of Missouri-Kansas City, Kansas City, Missouri, United States of America.ORCID https://orcid.org/0000-0002-6918-9871
Qing WuDepartment of Biomedical Informatics (Dr. Qing Wu, Jongyun Jung, and Jingyuan Dai), College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.ORCID https://orcid.org/0000-0003-4679-8903
The Ohio State University · USUniversity of Missouri–Kansas City · US

Funding

The Genome Analysis and Sequencing Pipeline (GASP)P20GM121325 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI CHEN, JINGCHUN · 2018 to 2022
$11.5M
Does Creating Person-specific Precision Thresholds Enhance the Ability of a Single Bone Density Measure to Predict Fractures in Minority Women?R01AG080017 · NIA · OHIO STATE UNIVERSITY · PI Qing Wu · 2024 to 2026
$1.9M
Precise Bone Density Reference Ranges to Reduce Systematic Disparities in Osteoporosis Healthcare for Hispanic WomenR21MD013681 · NIMHD · UNIVERSITY OF NEVADA LAS VEGAS · PI WU, QING · 2022 to 2023
$405k
NIA NIH HHS R01 AG080017NIGMS NIH HHS P20 GM121325NIMHD NIH HHS R21 MD013681
6 · The paper itself

Abstract

Artificial Intelligence (AI), encompassing Machine Learning and Deep Learning, has increasingly been applied to fracture detection using diverse imaging modalities and data types. This systematic review and meta-analysis aimed to assess the efficacy of AI in detecting fractures through various imaging modalities and data types (image, tabular, or both) and to synthesize the existing evidence related to AI-based fracture detection. Peer-reviewed studies developing and validating AI for fracture detection were identified through searches in multiple electronic databases without time limitations. A hierarchical meta-analysis model was used to calculate pooled sensitivity and specificity. A diagnostic accuracy quality assessment was performed to evaluate bias and applicability. Of the 66 eligible studies, 54 identified fractures using imaging-related data, nine using tabular data, and three using both. Vertebral fractures were the most common outcome (n = 20), followed by hip fractures (n = 18). Hip fractures exhibited the highest pooled sensitivity (92%; 95% CI: 87-96, p< 0.01) and specificity (90%; 95% CI: 85-93, p< 0.01). Pooled sensitivity and specificity using image data (92%; 95% CI: 90-94, p< 0.01; and 91%; 95% CI: 88-93, p < 0.01) were higher than those using tabular data (81%; 95% CI: 77-85, p< 0.01; and 83%; 95% CI: 76-88, p < 0.01), respectively. Radiographs demonstrated the highest pooled sensitivity (94%; 95% CI: 90-96, p < 0.01) and specificity (92%; 95% CI: 89-94, p< 0.01). Patient selection and reference standards were major concerns in assessing diagnostic accuracy for bias and applicability. AI displays high diagnostic accuracy for various fracture outcomes, indicating potential utility in healthcare systems for fracture diagnosis. However, enhanced transparency in reporting and adherence to standardized guidelines are necessary to improve the clinical applicability of AI. Review Registration: PROSPERO (CRD42021240359).

Identifiers

PMID38289965
PMCPMC10826962
OpenAlexW4391343068

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.