Evidence map›Paper›PMID 38289867›Full record

Observational studyEuropean heart journal2024

Electrical storm treatment by percutaneous stellate ganglion block: the STAR study.

Simone Savastano, Enrico Baldi, Sara Compagnoni, Roberto Rordorf, Antonio Sanzo, Francesca Romana Gentile, Veronica Dusi, Simone Frea, Carol Gravinese, Filippo Maria Cauti and 23 more

Erratum issued 2 registry-linked trialsOpen access · hybridAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
28.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07211347 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Percutaneous Blockade Protocol of the Stellate Ganglion in Patients With Refractory Electrical Storm

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2025 to 2028Enrolled64ConditionsElectrical Storm, Stellate Ganglion Block, Ventricular ArrhythmiaArmsStellate Ganglion Block
NCT07375264 completednot on this map

Long-term Outcomes of Ultrasound-guided Percutaneous Bilateral Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: a Single-center Case Series

Typeobservational_patient_registrySponsorJose Manuel López GonzálezRan2023 to 2025Enrolled18ConditionsVentricular Arrhythmias, Electrical Storm, Stellate Ganglion BlockArmsCardiac sympathetic denervation.
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
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  4. Continuous stellate ganglion block for ventricular arrhythmias: case series, systematic review, and differences from thoracic epidural anaesthesia.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Pooled it
  5. Percutaneous left stellate ganglion block for drug-refractory supraventricular arrhythmias in patients with advanced heart failure and cardiogenic shock: a pilot study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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  11. A practical 5-stage clinical scale for electrical storm: the STORM classification.European heart journal. Acute cardiovascular care · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 19 institutions in 1 country.

Simone SavastanoDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.ORCID 0000-0002-9789-6661
Enrico BaldiDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.ORCID 0000-0002-6360-224X
Sara CompagnoniDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.
Roberto RordorfDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.ORCID 0000-0003-4111-1690
Antonio SanzoDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.
Francesca Romana GentileDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.
Veronica DusiDivision of Cardiology, Molinette Hospital, Città della Salute e della Scienza, Torino, Italy.ORCID 0000-0002-2290-3126
Simone FreaDivision of Cardiology, Molinette Hospital, Città della Salute e della Scienza, Torino, Italy.
Carol GravineseDivision of Cardiology, Molinette Hospital, Città della Salute e della Scienza, Torino, Italy.
Filippo Maria CautiDivision of Cardiology, Fatebenefratelli Hospital, Rome, Italy.
Gianmarco IannopolloDivision of Cardiology, Maggiore Hospital, Bologna, Italy.
Francesco De SensiDivision of Cardiology, Misericordia Hospital, Grosseto, Italy.ORCID 0000-0002-9742-7101
Edoardo GandolfiDivision of Cardiology, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
Laura FrigerioDivision of Cardiology, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
Pasquale CreaDivision of Cardiology, G. Martino Hospital, Messina, Italy.
Domenico ZagariDivision of Cardiology, Humanitas Mater Domini, Castellanza, Italy.
Matteo CasulaDivision of Cardiology, 'San Michele' dell'ARNAS G. Brotzu Hospital, Cagliari, Italy.ORCID 0000-0002-3451-7484
Giuseppe SangiorgiDivision of Cardiology, 'Tor Vergata' University Hospital, Rome, Italy.
Simone PersampieriDivision of Cardiology, San Biagio Hospital, Domodossola, Italy.
Gabriele Dell'EraDivision of Cardiology, Maggiore della carità Hospital, Novara, Italy.
Giuseppe PattiDivision of Cardiology, Maggiore della carità Hospital, Novara, Italy.ORCID 0000-0002-5404-3968
Claudia ColomboDivision of Cardiology, 'A. De Gasperis', ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Giacomo MugnaiDivision of Cardiology, Department of Medicine, School of Medicine, University of Verona, Verona, Italy.
Francesco NotaristefanoDivision of Cardiology, Santa Maria della Misericordia Hospital, Perugia, Italy.ORCID 0000-0003-0904-6577
Alberto BarengoDivision of Cardiology, Santa Maria della Misericordia Hospital, Perugia, Italy.
Roberta FalcettiDivision of Cardiology, Sant'Andrea University Hospital, Rome, Italy.
Giovanni Battista PeregoDivision of Cardiology, San Luca Hospital, Milan, Italy.
Giuseppe D'AngeloDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Hospital and Vita-Salute University, Milan, Italy.
Nikita TaneseDepartment of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Hospital and Vita-Salute University, Milan, Italy.
Alessia CurraoDivision of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.
Vito SgromoAREU Azienda Regionale Emergenza Urgenza, AAT Pavia Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Gaetano Maria De FerrariDivision of Cardiology, Molinette Hospital, Città della Salute e della Scienza, Torino, Italy.ORCID 0000-0003-4940-0876
STAR study group
Policlinico San Matteo Fondazione · ITFondazione Ricerca Molinette · ITUniversity of Pavia · ITVita-Salute San Raffaele University · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITFatebenefratelli Hospital · ITOspedale Santa Maria · ITAgenzia Regionale Emergenza Urgenza · ITAzienda Ospedaliera G. Brotzu · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITAzienda Ospedaliera Ospedale Maggiore · ITAzienda Ospedaliera Sant'Andrea · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITHumanitas Mater Domini · ITIRCCS Istituto Auxologico Italiano · ITOspedale Misericordia - Grosseto · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Rome Tor Vergata · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAn electrical storm (ES) is a clinical emergency with a paucity of established treatment options. Despite initial encouraging reports about the safety and effectiveness of percutaneous stellate ganglion block (PSGB), many questions remained unsettled and evidence from a prospective multicentre study was still lacking. For these purposes, the STAR study was designed.

methodsThis is a multicentre observational study enrolling patients suffering from an ES refractory to standard treatment from 1 July 2017 to 30 June 2023. The primary outcome was the reduction of treated arrhythmic events by at least 50% comparing the 12 h following PSGB with the 12 h before the procedure. STAR operators were specifically trained to both the anterior anatomical and the lateral ultrasound-guided approach.

resultsA total of 131 patients from 19 centres were enrolled and underwent 184 PSGBs. Patients were mainly male (83.2%) with a median age of 68 (63.8-69.2) years and a depressed left ventricular ejection fraction (25.0 ± 12.3%). The primary outcome was reached in 92% of patients, and the median reduction of arrhythmic episodes between 12 h before and after PSGB was 100% (interquartile range -100% to -92.3%). Arrhythmic episodes requiring treatment were significantly reduced comparing 12 h before the first PSGB with 12 h after the last procedure [six (3-15.8) vs. 0 (0-1), P < .0001] and comparing 1 h before with 1 h after each procedure [2 (0-6) vs. 0 (0-0), P < .001]. One major complication occurred (0.5%).

conclusionsThe findings of this large, prospective, multicentre study provide evidence in favour of the effectiveness and safety of PSGB for the treatment of refractory ES.

Indexed as

Tachycardia, VentricularAgedFemaleHumansMaleMiddle AgedProspective StudiesStellate GanglionStroke VolumeTreatment OutcomeVentricular FibrillationVentricular Function, LeftElectrical stormNeuromodulationStellate ganglion blockVentricular tachycardia

Identifiers

PMID38289867
PMCPMC10919918
OpenAlexW4391344073

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.